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Article
Granisetron, tropisetron, and ondansetron in the prevention of acute emesis induced by a combination of cisplatin–Adriamycin and by high-dose ifosfamide delivered in multiple-day continuous infusions
The antiemetic efficacy of granisetron, ondansetron and tropisetron was evaluated in patients treated with cisplatin–Adriamycin (CDP/ADM) and ifosfamide (IFO) by continuous infusion (CI). In all, 90 patients ...
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Chapter
Autologous Peripheral Blood Stem Cell Transplantation in Childhood Metastatic Osteosarcoma
Over the past few years the outcome of patients with high grade osteosarcoma (OST) improved dramatically, with survival rates rising from 15% up to 70% [1]. The relatively large series of subjects reported by ...
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Chapter
Autologous Peripheral Blood Stem Cell Transplantation in Childhood Metastatic Osteosarcoma
Over the past few years the outcome of patients with high grade osteosarcoma (OST) has improved dramatically with survival rates rising from 15% up to 70% [1]. The relatively large series of subjects reported ...
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Chapter
Surgery of Osteosarcoma of the extremities: Indications and complications in the recent Experience at the Istituto Ortopedico Rizzoli
In the surgical treatment of localized osteosarcoma of the extremities, limb-salvage procedures are currently used whenever wide surgical margins can be achieved [1–3]. The increased indications for conservative ...
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Chapter
Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities: The recent experience at the Rizzoli Institute
In the late 1970s Rosen et al. was the first to report the advantages of primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) over adjuvant chemotherapy. The excellent results reported by these ...
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Chapter and Conference Paper
Segmental Allograft Reconstruction Concomitant with Neoadjuvant Chemotherapy
The effect of chemotherapy on the outcome of allograft reconstruction procedures after the resection of bone tumors is of considerable interest in the light of both experimental [1,2] and clinical evidence [3,...
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Chapter and Conference Paper
The Effect of Chemotherapy on Uncemented Prosthetic Replacement
Recently, pre- and/or postoperative chemotherapy has been widely used to achieve better general and local control of high grade bone sarcomas. With neoadjuvant treatment, limb salvage is now performed in about...
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Chapter and Conference Paper
Neo-adjuvant Chemotherapy for Osteosarcoma of the Extremities: The Experience at the Rizzoli Institute in 210 Patients Treated with Two Successively Activated Preoperative Protocols Using High-Dose or Moderate-Dose Methotrexate + Cisplatin or High-Dose Methotrexate + Cisplatin + Doxorubicin
The prognosis of localized osteosarcoma of the extremities (LOE) treated by surgery alone is very poor. In our experience, in spite of amputation, the disease-free survival rate for these patients is only 10%....
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Chapter
Telangiectatic or Hemorrhagic Osteosarcoma of Bone: A Clinicopathologic Study of 41 Patients at the Rizzoli Institute
Forty-one patients were treated for telangiectatic osteogenic sarcoma of bones at the Rizzoli Orthopaedic Institute in Bologna, Italy. Age, sex, and symptoms were those of usual osteosarcoma. Radiographically,...
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Chapter and Conference Paper
Neoadjuvant Chemotherapy for Osteosarcoma
From March 1983 to September 1986, 126 patients with localized high-grade osteosarcoma of the extremities were treated with neoadjuvant chemotherapy. Preoperative treatment consisted of two cycles of i.v. meth...
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Chapter
Neoadjuvant Chemotherapy for Osteosarcoma — Results of a Prospective Study
In March 1983, the Bone Tumor Center of the Istituto Ortopedico Rizzoli of Bologna, in collaboration with the Department of Pediatric Oncology of the University of Torino, and the 3rd Pediatric Clinic of the U...
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Chapter
Results of a Randomized Trial for the Treatment of Localized Soft Tissue Tumors (STS) of the Extremities in Adult Patients
The purpose of the protocol was to obtain a homogeneous group of adult patients with localized and high grade STS in an extremity (including pelvic and shoulder girdle) treated with three different local surgi...
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Chapter
Pelvic Resection in Bone Sarcomas
Between 1968 and 1986, 77 pelvic resections were performed at the Istituto Ortopedico Rizzoli for the treatment of primary bone tumors. There were 73 malignant tumors: 35 were low grade (all chondrosarcomas) a...
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Chapter
The Role of the Pathologist in the Treatment of Osteosarcoma
The role of the pathologist has changed in the modern treatment of osteosarcoma. Not only must the correct diagnosis be made, but also:
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