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Article
Pharmacokinetics of dipyridamole-β-cyclodextrin complex in healthy volunteers after single and multiple doses
Dipyridamole is a well known anti-aggregating agent characterized by poor water solubility as well as scant and variable bioavailability. Recently, the compound was complexed with β-cyclodextrin forming a mole...
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Article
Effects of erdosteine on sputum biochemical and rheologic properties: Pharmacokinetics in chronic obstructive lung disease
Erdosteine is a new thioderivative endowed with mucokinetic, mucolytic, and free-radical-scavenging properties. This study evaluated (in a double-blind design vs. placebo) its efficacy on biochemical and rheol...
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Article
Neuroleptic-induced prolactin rise: Influence of pharmacological alterations of different neurotransmitter systems
Oral administration of 2 neuroleptic drugs, haloperidol and LR511 induced in male rats a marked, dose-dependent and sustained rise of plasma prolactin.
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Article
10-Methoxyergoline derivatives asα-adrenergic blocking agents
Vengono descritte le attività adrenolitiche di una nuova classe di derivati dell'ergolina di formula generale IV. Uno di questi composti (No. 20) è stato esaminato su diversi reattivi biologici che hanno messo...
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Article
Abstracts
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Article
Structure-activity relationship of various acyl derivatives of 6-methyl-8β-aminomethyl-10α-ergoline (dihydrolysergamine)
Alcuni acil derivati dell'ergoline hanno dimostrato notevoli proprietà ossitociche, adrenolitiche ed anti-5-idrossitriptaminiche, (anti-5-HT). In particolare l'acetil e l'isobutirril diidrolisergamina possiedo...
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Chapter and Conference Paper
Cardiovascular Actions of Physalaemin
Physalaemin and eledoisin and perhaps substance P belong to a group of peptides having similar pharmacological actions (Bertaccini et al., 1965a,b) both in vitro and in vivo. In vivo, these peptides affect the...