20 Result(s)
within
G Hofstetter
English
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Chapter and Conference Paper
Steady-State Pharmacokinetics of Nisoldipine in Patients with Liver Disease
Seven patients with liver disease (fatty liver, chronic hepatitis, liver cirrhosis) were treated with 5 mg nisoldipine daily for up to 21 days. Trough plasma levels reached 0.22 ± 0.22 ng/ml (range 0.10–0.99 n...
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Chapter
Absorption of Hexobarbital und Caffeine in Patients with Liver Cirrhosis
Hexobarbital and caffeine elimination is impaired in patients with hepatitis and liver cirrhosis according to the severity of the disease. However, absorption of both substances is not altered in patients with...
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Article
Factors influencing the caffeine test for cytochrome P 448-dependent liver function
Liver function in patients with liver disease can be estimated by caffeine clearance. Our data, however, demonstrate the additional influence of factors other than liver disease on the caffeine test. Smoking e...
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Chapter and Conference Paper
Coupling of FE- and BE-Discretizations for 3D-Stress Analysis of Tunnels in Layered Anisotropic Rock
After introducing the method developed for the coupling of finite element (FE) and boundary element (BE) discretizations of subregions of solids, comments on the inadmissibility of symmetrizing the resulting c...
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Chapter
Long-Time Deformations and Creepbuckling of Prestressed Concrete Shells
The paper contains a report on the theoretical fundamentals of the extension of a computer program for geometrically and physically nonlinear finite element analysis of reinforced concrete shells to prestresse...
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Chapter
A Comparison of Two Variational Formulations for Rubber-Like Materials
Two different variational formulations for rubber-like materials within the framework of the finite element method are briefly reviewed. The first formulation deals with the constraint of incompressible materi...
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Article
Computational plasticity of reinforced and prestressed concrete structures
This paper contains a summary of a survey of computational mechanics of reinforced and prestressed concrete structures. It begins with a description of some very important experimental results. Subsequently, m...
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Chapter and Conference Paper
A Symmetric Coupled Fe-Be Method for Vibrating Structures Interacting with an Acoustic Fluid
In order to take the interactions between the vibrations of an elastic structure and the sound field in the surrounding fluid into account, a standard finite element formulation for the dynamic behavior of ela...
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Article
Cryopreservation of a Whole Ovary As a Strategy for Restoring Ovarian Function
Purpose: To evaluate whether a total ovary can successfully be cryopreserved and thawed under maintenance of high proportions of structurally normal primordial follicles.
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Chapter and Conference Paper
Validation of an extended cap model for partially saturated soils
The present paper deals with the development and validation of an elasto-plastic material model for partially saturated soils.
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Article
Alternative splicing of p53 and p73: the novel p53 splice variant p53δ is an independent prognostic marker in ovarian cancer
Similar to p73, the tumor suppressor gene p53 is subject to alternative splicing. Besides p53ΔE6 and p53β, we identified p53ζ, p53δ and p53ɛ, arising from alternative splicing of exon 6 and intron 9, respectively...
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Chapter and Conference Paper
A NUMERICAL MODEL FOR GEOTECHNICAL PROBLEMS INVOLVING PARTIALLY SATURATED SOILS
The paper deals with a numeric model for coupled solid–fluid FE analyses of geotechnical problems involving partially saturated soils. The Barcelona Basic Model serves as a constitutive model for the soil skel...
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Chapter
Plasticity based crack models and applications
Models for the numerical simulation of concrete cracking are traditionally based either on the smeared crack approach or the discrete crack approach.
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Article
Regulation of transcription factor E2F3a and its clinical relevance in ovarian cancer
Recently we showed an integral epidermal growth factor receptor (EGFR)–E2F3a signaling path, in which E2F3a was found to be essential in EGFR-mediated proliferation in ovarian cancer cells. The present work ev...
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Article
Open AccessΔ133p53 is an independent prognostic marker in p53 mutant advanced serous ovarian cancer
We aimed to evaluate the clinical relevance of p53 and p73 isoforms that modulate the function of p53.
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Article
Open AccessPrognostic significance of gamma-glutamyltransferase in patients with endometrial cancer: a multi-centre trial
Gamma-glutamyltransferase (GTT), a known marker for apoptotic balance, seems to promote tumour progression, invasion and drug resistance. Recently, high GGT serum levels were shown to be associated with impair...
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Article
Open AccessNomogram prediction for overall survival of patients diagnosed with cervical cancer
Nomograms are predictive tools that are widely used for estimating cancer prognosis. The aim of this study was to develop a nomogram for the prediction of overall survival (OS) in patients diagnosed with cervi...
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Article
Open AccessDoes thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial
Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating h...
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Article
Open AccessAssociation of gamma-glutamyltransferase with severity of disease at diagnosis and prognosis of ovarian cancer
Gamma-glutamyltransferase (GGT) – a membrane-bound enzyme crucially involved in the cell’s detoxification pathway and apoptotic balance – is involved in tumour development, progression and chemotherapy resista...
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Chapter
Multi-Phase Models in Civil Engineering
Some problems in civil engineering require the consideration of interactions between solids and fluids and/or between different physical phenomena, like thermal, hygral or chemical processes, for an appropriat...
