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Article
Palbociclib in highly pretreated metastatic ER-positive HER2-negative breast cancer
We aimed to investigate the role of palbociclib, a first-in-class cyclin-dependent kinase 4 and 6 inhibitor, in postmenopausal women with highly pretreated endocrine therapy-resistant metastatic breast cancer ...
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Article
Suppression of acetylpolyamine oxidase by selected AP-1 members regulates DNp73 abundance: mechanistic insights for overcoming DNp73-mediated resistance to chemotherapeutic drugs
Enhanced resistance to chemotherapy has been correlated with high levels of Delta-Np73 (DNp73), an anti-apoptotic protein of the p53 tumor-suppressor family which inhibits the pro-apoptotic members such as p53...
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Article
Open AccessAssociation of gamma-glutamyltransferase with severity of disease at diagnosis and prognosis of ovarian cancer
Gamma-glutamyltransferase (GGT) – a membrane-bound enzyme crucially involved in the cell’s detoxification pathway and apoptotic balance – is involved in tumour development, progression and chemotherapy resista...
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Article
Open AccessDoes thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial
Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating h...
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Article
Open AccessNomogram prediction for overall survival of patients diagnosed with cervical cancer
Nomograms are predictive tools that are widely used for estimating cancer prognosis. The aim of this study was to develop a nomogram for the prediction of overall survival (OS) in patients diagnosed with cervi...
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Article
Open AccessPrognostic significance of gamma-glutamyltransferase in patients with endometrial cancer: a multi-centre trial
Gamma-glutamyltransferase (GTT), a known marker for apoptotic balance, seems to promote tumour progression, invasion and drug resistance. Recently, high GGT serum levels were shown to be associated with impair...
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Article
Open AccessΔ133p53 is an independent prognostic marker in p53 mutant advanced serous ovarian cancer
We aimed to evaluate the clinical relevance of p53 and p73 isoforms that modulate the function of p53.
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Article
Regulation of transcription factor E2F3a and its clinical relevance in ovarian cancer
Recently we showed an integral epidermal growth factor receptor (EGFR)–E2F3a signaling path, in which E2F3a was found to be essential in EGFR-mediated proliferation in ovarian cancer cells. The present work ev...
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Article
Alternative splicing of p53 and p73: the novel p53 splice variant p53δ is an independent prognostic marker in ovarian cancer
Similar to p73, the tumor suppressor gene p53 is subject to alternative splicing. Besides p53ΔE6 and p53β, we identified p53ζ, p53δ and p53ɛ, arising from alternative splicing of exon 6 and intron 9, respectively...
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Article
Primary chemotherapy and maintenance therapy in epithelial ovarian cancer
PURPOSE. This overview summarizes the most prominent data on the evolution of first-line and maintenance chemotherapy in epithelial ovarian cancer. METHODS. The literature published on first-line and maintenan...
