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  1. Article

    Open Access

    The human papillomavirus (HPV) E7 protein antagonises an Imiquimod-induced inflammatory pathway in primary human keratinocytes

    High-risk human papillomaviruses (HPV) are the etiological pathogen of cervical and a number of ano-genital cancers. How HPVs overcome the significant barriers of the skin immune system has been the topic of i...

    Kathryn H. Richards, Christopher W. Wasson, Oliver Watherston… in Scientific Reports (2015)

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  2. Article

    Open Access

    CUB Domain Containing Protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells

    Deregulated expression of the transmembrane glycoprotein CDCP1 (CUB domain-containing protein-1) has been detected in several cancers including colon, lung, gastric, breast, and pancreatic carcinomas. CDCP1 ha...

    David J Orchard-Webb, Thong Chuan Lee, Graham P Cook, G Eric Blair in BMC Cancer (2014)

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  3. Article

    Open Access

    Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation

    Cells transformed by human adenoviruses (Ad) exhibit differential capacities to induce tumours in immunocompetent rodents; for example, Ad12-transformed rodent cells are oncogenic whereas Ad5-transformed cells...

    Janet Strath, Lindsay J Georgopoulos, Paul Kellam, G Eric Blair in BMC Genomics (2009)

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  4. No Access

    Protocol

    A Flow Cytometric Assay for Analysis of Natural-Killer Cell-Mediated Cytolysis of Adenovirus-Transformed Cells

    Natural-killer (NK) cells play an important role in recognizing and eliminating virally infected and transformed cells. To study this process, convenient assays for NK-cell function are required. Conventional ...

    Graham Bottley, Graham P. Cook, G. Eric Blair in Adenovirus Methods and Protocols (2007)

  5. No Access

    Article

    Adenoviral vectors: Adenoviral vectors, breaking a barrier to gene therapy?

    G Eric Blair in Gene Therapy (2004)

  6. No Access

    Article

    Transcriptional regulation of the major histocompatibility complex (MHC) class I heavy chain, TAP1 and LMP2 genes by the human papillomavirus (HPV) type 6b, 16 and 18 E7 oncoproteins

    We have examined the possibility that the E7 proteins of the high-risk human papillomavirus (HPV) type 16 and 18 and the oncogenic adenovirus (Ad) type 12 E1A protein share the ability to down-regulate the exp...

    Nikolaos T Georgopoulos, Joanne L Proffitt, G Eric Blair in Oncogene (2000)

  7. No Access

    Article

    Stable and temperature-sensitive transformation of baby rat kidney cells by SV40 suppresses expression of membrane dipeptidase

    Membrane dipeptidase (MDP) is a zinc metalloenzyme located in the lungs and on the brush border membranes of the kidney and intestine. The gene for MDP (also termed DPEP1) is both frequently lost in Wilm's tum...

    Shoshana Keynan, Aruna Asipu, Nigel M Hooper, Anthony J Turner, G Eric Blair in Oncogene (1997)

  8. No Access

    Article

    The immunomodulatory effect of levamisole is influenced by postoperative changes and type of lymphocyte stimulant

    The results of both laboratory and clinical research into the immunomodulatory activity of levamisole have shown a considerable degree of inconsistency and sometimes contradiction. This is probably a reflectio...

    ElMuataz E. AbdAlla, Ian J. Adam, G. Eric Blair… in Cancer Immunology, Immunotherapy (1995)