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  1. No Access

    Article

    Relationships between the expression of adipose genes and profiles of hospitalized dogs

    Obesity is one of the risk factors for the onset of various metabolic diseases in dogs. Energy expenditure in brown/beige adipocytes, which is partially regulated by the bone morphogenetic protein (BMP) pathwa...

    Yukina Sugiyama, Fumie Shimokawa, Kazutoshi Sugiyama… in Veterinary Research Communications (2022)

  2. Article

    Open Access

    Response to iron overload in cultured hepatocytes

    Iron is essential for a variety of physiological processes. Hepatic iron overload acts as a trigger for the progression of hepatic steatosis to nonalcoholic steatohepatitis and hepatocellular carcinoma. In the...

    Hsuan-Ju Chen, Makoto Sugiyama, Fumie Shimokawa, Masaru Murakami… in Scientific Reports (2020)

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    Article

    Relationships between expression levels of genes related to adipogenesis and adipocyte function in dogs

    There are three kinds of adipocytes; white adipocytes accumulate excess energy as fat, whereas brown/beige adipocytes dissipate energy through expression of uncoupling protein 1 (UCP1). Obesity, a feature of e...

    Mikako Motomura, Fumie Shimokawa, Takashi Kobayashi… in Molecular Biology Reports (2019)

  4. No Access

    Article

    TGF-β Negatively Regulates Mitf-E Expression and Canine Osteoclastogenesis

    With longevity, the prevalence of osteoporosis, which occurs when the activity of osteoclast surpasses that of osteoblasts, has increased in dogs. However, limited information is available on canine osteoclast...

    Kumiko Asai, Masaharu Hisasue, Fumie Shimokawa, Masayuki Funaba… in Biochemical Genetics (2018)