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Article
Longitudinal analysis of blood pressure and lipids in childhood nephrotic syndrome
In the current study, longitudinal BP and lipid measurements were examined in a NEPTUNE cohort of children with newly diagnosed nephrotic syndrome (cNEPTUNE). We hypothesized that hypertensive BP and dyslipide...
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Article
Growth in children with nephrotic syndrome: a post hoc analysis of the NEPTUNE study
Steroids, the mainstay of treatment for nephrotic syndrome in children, have multiple adverse effects including growth suppression.
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Article
The first randomized controlled trial in pediatric nephrology: the history of the International Study of Kidney Disease in Children (ISKDC)
The International Study of Kidney Disease in Children (ISKDC), begun in 1966, conducted the first international collaborative randomized blinded controlled trial in pediatric nephrology and one of the first in...
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Article
Determinants of medication adherence in childhood nephrotic syndrome and associations of adherence with clinical outcomes
Pediatric patients with nephrotic syndrome take medications long-term with significant toxicity and complex regimens, yet data on medication adherence are limited.
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Article
Adrian Spitzer, MD: a pioneer in developmental renal physiology
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Article
Progressive kidney disease may not alter the association of hyponatremia with mortality
Hyponatremia is a common electrolyte disorder and a prognostic marker for mortality. We hypothesize that in advanced chronic or acute kidney disease, hyponatremia is not independently associated with mortality...
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Article
Enhancing clinical trial development for pediatric kidney diseases
The conduct of clinical trials in small pediatric subspecialties such as pediatric nephrology is hampered by both clinical demands on the pediatric nephrologist and the small number of appropriate patients ava...
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Article
Steroid-resistant nephrotic syndrome: a persistent challenge for pediatric nephrology
Steroid-resistant nephrotic syndrome remains a challenge to treat, but various efforts are underway to better understand the pathogenesis and improve patient outcomes. This review provides an update on the new...
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Article
Primary hyperoxaluria: spectrum of clinical and imaging findings
Primary hyperoxaluria is a rare autosomal recessive inborn error of metabolism with three known subtypes. In primary hyperoxaluria type 1, the most common of the subtypes, a deficiency in the hepatic enzymes r...
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Article
Dr. Ira Greifer
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Article
An 18-year-old with nephrotic syndrome and chest pain: Questions
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An 18-year-old with nephrotic syndrome and chest pain: Answers
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Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota
Emerging evidence suggests an association between food sensitivity and gut microbiota in children with nephrotic syndrome. Diminished proteinuria resulted from eliminating cow’s milk and the use of an oligoant...
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Article
Open AccessGrowth hormone axis in chronic kidney disease
Chronic kidney disease (CKD) in children is associated with dramatic changes in the growth hormone (GH) and insulin-like growth factor (IGF-1) axis, resulting in growth retardation. Moderate-to-severe growth r...
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The association of anemia and hypoalbuminemia with accelerated decline in GFR among adolescents with chronic kidney disease
We sought to describe rates of kidney function decline and to identify modifiable risk factors for CKD progression in a multicenter prospective cohort study of adolescents with CKD aged 11 to 18 years seen sem...
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Article
Role of folate deficiency on erythropoietin resistance in pediatric and adolescent patients on chronic dialysis
Unlike iron therapy, folate use is not a standard of care in hemodialysis (HD) patients. Despite iron repletion, poor response to erythropoietin (EPO) treatment is common. Theoretical evidence for folate defic...
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Article
First NIH/Office of Rare Diseases Conference on Cystinosis: past, present, and future
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Impact of residual renal function in children on hemodialysis
Residual renal function (RRF) contributes to dialysis adequacy as well as lower mortality and morbidity in dialysis patients. Even very small changes in glomerular filtration rate (GFR) account for considerab...
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Article
Basiliximab induction improves the outcome of renal transplants in children and adolescents
Thirty-two children and adolescents received their renal transplant at the Montefiore Medical Center, in New York, between October 1996 and May 2000. Twenty-four patients received basiliximab, in addition to ...
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Article
Novel WT1 mutation (C388Y) in a female child with Denys-Drash syndrome
We report the identification of a novel Wilms tumor suppressor gene mutation in a 5-month-old girl who presented with unilateral Wilms tumor (WT) and renal diffuse mesangial sclerosis typical of Denys-Drash sy...