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Article
Open AccessA single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity
Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwid...
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Article
Open AccessMap** human norovirus antigens during infection reveals the breadth of the humoral immune response
Human noroviruses (HuNoV) are the leading cause of acute gastroenteritis worldwide. The humoral immune response plays an important role in clearing HuNoV infections and elucidating the antigenic landscape of H...
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Article
Open AccessCLIC and membrane wound repair pathways enable pandemic norovirus entry and infection
Globally, most cases of gastroenteritis are caused by pandemic GII.4 human norovirus (HuNoV) strains with no approved therapies or vaccines available. The cellular pathways that these strains exploit for cell ...
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Article
Open AccessSecretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses
Our previous report that the Norwalk virus nonstructural protein p22 is an antagonist of the cellular secretory pathway suggests a new aspect of norovirus/host interaction. To explore conservation of function ...
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Protocol
Detection of Human Caliciviruses in Fecal Samples by RT-PCR
Human caliciviruses, noroviruses in particular, are a common cause of gastroenteritis in persons of all age groups. Although both antigen detection and serologic methods for diagnosis of infection with these v...
