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  1. Article

    Open Access

    Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

    Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esoph...

    Wei Cao, Hayan Lee, Wei Wu, Aubhishek Zaman, Sean McCorkle… in Nature Communications (2020)

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    Chapter

    Evolutionary Dynamics of a Population of Cells with a Toxin Suppressor Gene

    Environmental changes are known to trigger evolutionary changes, e.g. by favoring higher mutation rates. We study the evolutionary dynamics of a delayed stochastic genetic circuit using a simulator developed f...

    Antti Häkkinen, Fred G. Biddle… in Transactions on Computational Systems Biol… (2011)

  3. No Access

    Chapter

    Biological Limits of Hand Preference Learning Hiding Behind the Genes

    Biological limits of learning are the cto our understanding of learning and memory. We are conducting a detailed investigation of structure and function of gene regulatory networks in a biological system of le...

    Fred G. Biddle, Brenda A. Eales in Information Processing and Biological Systems (2011)

  4. No Access

    Article

    The degree of lateralization of paw usage (handedness) in the mouse is defined by three major phenotypes

    Lateralization of paw usage in the laboratory mouse may be a useful model system in which to assess the genetic and developmental cause of asymmetry of hand usage. With a set number of paw reaches from a centr...

    Fred G. Biddle, Brenda A. Eales in Behavior Genetics (1996)

  5. No Access

    Article

    Purine nucleoside phosphorylase (Np) in the mouse: Linkage relationship of Np-2 to esterase-10 (Es-10) and Np-1 on chromosome 14

    An improved method for detecting four Np-1 (purine nucleoside phosphorylase) alleles in mouse erythrocytes by cellulose acetate electrophoresis is described. The previous linkage of Np-1 and Es-10 (esterase-10) w...

    Trevor Lukey, Kuldeep Neote, John F. Loman, Ardythe E. Unger… in Biochemical Genetics (1985)

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    Chapter

    Genetic Variability of Purine Nucleoside Phosphorylase in the Mouse

    The inherited human deficiency of purine nucleoside phosphorylase is associated primarily with cellular immune dysfunction1. We have begun to screen for quantitative activity variants of purine nucleoside phospho...

    Floyd F. Snyder, Fred G. Biddle, Trevor Lukey… in Purine Metabolism in Man-IV (1984)

  7. No Access

    Article

    Genetic variability of purine nucleoside phosphorylase activity in the mouse: Relationship to Np-1 and Np-2

    A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of...

    Floyd F. Snyder, Fred G. Biddle, Trevor Lukey, Marcia J. Sparling in Biochemical Genetics (1983)