12 Result(s)

Article

Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma

Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell states via altered gene expression values. Herein, we have developed a copy-number impact (CNI) analysis method that quantif...

Sanaz Jamalzadeh, Jun Dai, Kari Lavikka, Yilin Li, **g Jiang, Kaisa Huhtinen… in BMC Cancer (2024)

Article

Correction to: Formation of Humboldtine During the Dissolution of Hematite in Oxalic Acid – Density Functional Theory (DFT) Calculations and Experimental Verification

Paula Vehmaanperä, Bo Gong, Patrick H.-L. Sit, Riina Salmimies… in Clays and Clay Minerals (2023)

Article

FORMATION OF HUMBOLDTINE DURING THE DISSOLUTION OF HEMATITE IN OXALIC ACID – DENSITY FUNCTIONAL THEORY (DFT) CALCULATIONS AND EXPERIMENTAL VERIFICATION

Understanding the reactions taking place in the hematite-oxalic acid system is important in order to clean iron oxides from filters and to remove iron from mineral concentrates. Previous studies reported the f...

Paula Vehmaanperä, Bo Gong, Patrick H.-L. Sit, Riina Salmimies… in Clays and Clay Minerals (2021)

Article

Differential DNA methylation in recovery from shift work disorder

The human DNA methylome is responsive to our environment, but its dynamics remain underexplored. We investigated the temporal changes to DNA methylation (DNAme) in relation to recovery from a shift work disord...

Alexandra Lahtinen, Antti Häkkinen, Sampsa Puttonen, Päivi Vanttola… in Scientific Reports (2021)

Article

Thermodynamic and Kinetic Studies of Dissolution of Hematite in Mixtures of Oxalic and Sulfuric Acid

The dissolution of iron oxides in mixtures of acids is fairly uncommon but can result in a more efficient dissolution process. The objective in this work was to investigate the dissolution of synthetic hematit...

Paula Vehmaanperä, Riina Salmimies, Antti Häkkinen in Mining, Metallurgy & Exploration (2021)

Article

The lifelong socioeconomic disadvantage of single-mother background - the Helsinki Birth Cohort study 1934–1944

Growing up with one parent is associated with economic hardship and health disadvantages, but there is limited evidence of its lifetime consequences. We examined whether being born to an unmarried mother is as...

H. Maiju Mikkonen, Minna K. Salonen, Antti Häkkinen, Maarit Olkkola… in BMC Public Health (2016)

Article

Effects of multimerization on the temporal variability of protein complex abundance

We explore whether the process of multimerization can be used as a means to regulate noise in the abundance of functional protein complexes. Additionally, we analyze how this process affects the mean level of ...

Antti Häkkinen, Huy Tran, Olli Yli-Harja, Brian Ingalls… in BMC Systems Biology (2013)

Article

Detecting sequence dependent transcriptional pauses from RNA and protein number time series

Evidence suggests that in prokaryotes sequence-dependent transcriptional pauses affect the dynamics of transcription and translation, as well as of small genetic circuits. So far, a few pause-prone sequences h...

Frank Emmert-Streib, Antti Häkkinen, Andre S Ribeiro in BMC Bioinformatics (2012)

Article

In vivo kinetics of transcription initiation of the lar promoter in Escherichia coli. Evidence for a sequential mechanism with two rate-limiting steps

In Escherichia coli the mean and cell-to-cell diversity in RNA numbers of different genes vary widely. This is likely due to different kinetics of transcription initiation, a complex process with multiple rate-li...

Meenakshisundaram Kandhavelu, Henrik Mannerström, Abhishekh Gupta… in BMC Systems Biology (2011)