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Article
CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas
Diffuse invasion remains a primary cause of treatment failure in pediatric high-grade glioma (pHGG). Identifying cellular driver(s) of pHGG invasion is needed for anti-invasion therapies.
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Article
Open AccessTranslocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
TSPO is a promising novel tracer target for positron-emission tomography (PET) imaging of brain tumors. However, due to the heterogeneity of cell populations that contribute to the TSPO-PET signal, imaging int...
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Article
Open AccessTargeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models
Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for develo** new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It’s capacity...
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Article
Open AccessTSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma
Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with ma...
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Article
Open AccessPublisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas
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Article
Open AccessEpigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas
Recurrence is frequent in pediatric ependymoma (EPN). Our longitudinal integrated analysis of 30 patient-matched repeated relapses (3.67 ± 1.76 times) over 13 years (5.8 ± 3.8) reveals stable molecular subtype...
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Article
Preservation of KIT genotype in a novel pair of patient-derived orthotopic xenograft mouse models of metastatic pediatric CNS germinoma
Metastatic intracranial germinoma is difficult to treat. Although the proto-oncogene KIT is recognized as one of the most frequent genetic abnormalities in CNS germinoma, the development of new target therapeutic...
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Article
Open AccessTargeting Wnt pathway in mantle cell lymphoma-initiating cells
Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin’s lymphoma. Despite initial intense chemotherapy, up to 50 % of cases of MCL relapse often in a chemoresistant form. We hypothesize...
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Article
Open AccessCD74 interferes with the expression of fas receptor on the surface of lymphoma cells
Resistance to Fas-mediated apoptosis limits the efficacy of currently available chemotherapy regimens. We identified CD74, which is known to be overexpressed in hematological malignancies, as one of the factor...
