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Article
Open AccessTranslocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
TSPO is a promising novel tracer target for positron-emission tomography (PET) imaging of brain tumors. However, due to the heterogeneity of cell populations that contribute to the TSPO-PET signal, imaging int...
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Article
Open AccessTSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma
Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with ma...
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Article
Open AccessA comprehensive DNA panel next generation sequencing approach supporting diagnostics and therapy prediction in neurooncology
Recent updates in the classification of central nervous system (CNS) tumors have increased the need for molecular testing. Assessment of multiple alterations in parallel, complex combinations of gene sequence ...
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Article
Open AccessChronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions
The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin bindin...
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Article
Open AccessGenome-wide analysis of starch metabolism genes in potato (Solanum tuberosum L.)
Starch is the principle constituent of potato tubers and is of considerable importance for food and non-food applications. Its metabolism has been subject of extensive research over the past decades. Despite i...
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Article
Open AccessTissue-Engineering Strategies to Repair Chondral and Osteochondral Tissue in Osteoarthritis: Use of Mesenchymal Stem Cells
Focal chondral or osteochondral lesions can be painful and disabling because they have insufficient intrinsic repair potential, and constitute one of the major extrinsic risk factors for osteoarthritis (OA). A...
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Protocol
Experimental Osteoarthritis Models in Mice
Osteoarthritis (OA) is a slowly progressing, degenerative disorder of synovial joints culminating in the irreversible destruction of articular cartilage and subchondral bone. It affects almost everyone over th...
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Article
How mold inserts influence the replication of metallic microparts produced by electroplating into two-component templates
Multi-component injection molding combined with electroplating, the so-called MSG process, represents a promising process chain to replicate metallic microstructures. MSG is the German acronym of ‘Mehrkomponen...
