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Article
In Vivo Three-Dimensional Geometric Reconstruction of the Mouse Aortic Heart Valve
Aortic valve (AV) disease is a common valvular lesion in the United States, present in about 5% of the population at age 65 with increasing prevalence with advancing age. While current replacement heart valves...
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Chapter and Conference Paper
Optimizing BIT1, a Particle-in-Cell Monte Carlo Code, with OpenMP/OpenACC and GPU Acceleration
On the path toward develo** the first fusion energy devices, plasma simulations have become indispensable tools for supporting the design and development of fusion machines. Among these critical simulation t...
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Chapter and Conference Paper
Krylov Solvers for Interior Point Methods with Applications in Radiation Therapy and Support Vector Machines
Interior point methods are widely used for different types of mathematical optimization problems. Many implementations of interior point methods in use today rely on direct linear solvers to solve systems of e...
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Chapter and Conference Paper
Distributed Objective Function Evaluation for Optimization of Radiation Therapy Treatment Plans
The modern workflow for radiation therapy treatment planning involves mathematical optimization to determine optimal treatment machine parameters for each patient case. The optimization problems can be computa...
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Chapter and Conference Paper
Parallel Cholesky Factorization for Banded Matrices Using OpenMP Tasks
Cholesky factorization is a method for solving linear systems involving symmetric, positive-definite matrices, and can be an attractive choice in applications where a high degree of numerical stability is need...
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Article
Open AccessA survey of HPC algorithms and frameworks for large-scale gradient-based nonlinear optimization
Large-scale numerical optimization problems arise from many fields and have applications in both industrial and academic contexts. Finding solutions to such optimization problems efficiently requires algorithm...
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Article
Open AccessUncovering associations between data-driven learned qMRI biomarkers and chronic pain
Knee pain is the most common and debilitating symptom of knee osteoarthritis (OA). While there is a perceived association between OA imaging biomarkers and pain, there are weak or conflicting findings for this...
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Article
Open AccessDeep learning for large scale MRI-based morphological phenoty** of osteoarthritis
Osteoarthritis (OA) develops through heterogenous pathophysiologic pathways. As a result, no regulatory agency approved disease modifying OA drugs are available to date. Stratifying knees into MRI-based morpho...
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Article
Open AccessBone shape mediates the relationship between sex and incident knee osteoarthritis
Knee bone shape differs between men and women and the incidence of knee osteoarthritis (OA) is higher in women than in men. Therefore, the purpose of the present study was to determine whether the observed dif...
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Article
Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative
To investigate the association of weight change over 48 months with progression of meniscal intrasubstance degeneration (MID).
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Article
What has imaging contributed to the epidemiological understanding of osteoarthritis?
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Article
Open AccessTransmurality map** of left ventricular scar: impact of spatial resoluton
