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  1. No Access

    Article

    Amplification-free digital gene expression profiling from minute cell quantities

    On-flowcell capture and reverse transcription followed by single-molecule cDNA sequencing provides reproducible digital gene expression results from as few as 1,000 cells.

    Fatih Ozsolak, David T Ting, Ben S Wittner, Brian W Brannigan… in Nature Methods (2010)

  2. No Access

    Article

    Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA

    Single-molecule sequencing of poly(A)-tailed chromatin immunoprecipitated DNA proves equal in sensitivity and accuracy to amplification-based sequencing technologies and allows analysis of samples sizes as sma...

    Alon Goren, Fatih Ozsolak, Noam Shoresh, Manching Ku, Mazhar Adli… in Nature Methods (2010)

  3. No Access

    Article

    High-throughput map** of the chromatin structure of human promoters

    Our understanding of how chromatin structure influences cellular processes such as transcription and replication has been limited by a lack of nucleosome-positioning data in human cells. We describe a high-res...

    Fatih Ozsolak, Jun S Song, X Shirley Liu, David E Fisher in Nature Biotechnology (2007)

  4. Article

    Open Access

    Comparison of dot chromosome sequences from D. melanogaster and D. virilisreveals an enrichment of DNA transposon sequences in heterochromatic domains

    Chromosome four of Drosophila melanogaster, known as the dot chromosome, is largely heterochromatic, as shown by immunofluorescent staining with antibodies to heterochromatin protein 1 (HP1) and histone H3K9me. I...

    Elizabeth E Slawson, Christopher D Shaffer, Colin D Malone, Wilson Leung… in Genome Biology (2006)

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