32 Result(s)

Article

Proceedings of the inaugural Dark Genome Symposium: November 2022

In November 2022 the first Dark Genome Symposium was held in Boston, USA. The meeting was hosted by Rome Therapeutics and Enara Bio, two biotechnology companies working on translating our growing understanding...

Jef D. Boeke, Kathleen H. Burns, Katherine B. Chiappinelli, Marie Classon… in Mobile DNA (2023)

Article

SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers

Adult liver malignancies, including intrahepatic cholangiocarcinoma and hepatocellular carcinoma, are the second leading cause of cancer-related deaths worldwide. Most individuals are treated with either combi...

Lei Shi, William Shen, Mindy I. Davis, Ke Kong, Phuong Vu, Supriya K. Saha… in Nature Cancer (2023)

Article

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a com...

Niyati Desai, Azfar Neyaz, Annamaria Szabolcs, Angela R. Shih… in Nature Communications (2020)

Article

HIF1A signaling selectively supports proliferation of breast cancer in the brain

Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular pathways that enable cancer cells to selectively grow in the brain microenvironment are poorly understood. We find tha...

Richard Y. Ebright, Marcus A. Zachariah, Douglas S. Micalizzi… in Nature Communications (2020)

Article

Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target

Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight into metastasis and guide develo...

Joseph W. Franses, Julia Philipp, Pavlos Missios, Irun Bhan… in Nature Communications (2020)

Article

GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma

Monocytes, macrophages and microglia make up a large part of the glioma environment and have an important role in maintaining and propagating glioma progression. Targeting these cells to inhibit their tumor-pr...

Erik R. Abels, Sybren L. N. Maas, Eric Tai, David T. Ting… in Scientific Reports (2020)

Article

Glioblastoma hijacks microglial gene expression to support tumor growth

Glioblastomas are the most common and lethal primary brain tumors. Microglia, the resident immune cells of the brain, survey their environment and respond to pathogens, toxins, and tumors. Glioblastoma cells c...

Sybren L. N. Maas, Erik R. Abels, Lieke L. Van De Haar… in Journal of Neuroinflammation (2020)

Article

Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Aparna R. Parikh, Ignaty Leshchiner, Liudmila Elagina, Lipika Goyal… in Nature Medicine (2019)

Article

A tumor-specific endogenous repetitive element is induced by herpesviruses

Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction...

Maciej T. Nogalski, Alexander Solovyov, Anupriya S. Kulkarni… in Nature Communications (2019)

Article

Relationship between hepatocellular carcinoma circulating tumor cells and tumor volume

Microfluidic platforms have demonstrated the ability to isolate rare circulating tumor cells from a wide variety of cancers. Our group has recently shown the ability to isolate circulating tumor cells (CTCs) f...

Rahmi Oklu, Rahul Sheth, Hassan Albadawi, Irun Bhan… in Cancer Convergence (2018)

Article

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles

Extracellular vesicles (EVs) carry RNA, DNA, proteins, and lipids. Specifically, tumor-derived EVs have the potential to be utilized as disease-specific biomarkers. However, a lack of methods to isolate tumor-...

Eduardo Reátegui, Kristan E. van der Vos, Charles P. Lai… in Nature Communications (2018)

Article

Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells

Precise rare-cell technologies require the blood to be processed immediately or be stabilized with fixatives. Such restrictions limit the translation of circulating tumor cell (CTC)-based liquid biopsy assays ...

Keith H. K. Wong, Shannon N. Tessier, David T. Miyamoto… in Nature Communications (2017)

Article

Introducing cancer convergence

Krastan B. Blagoev, David T. Ting, Herbert Levine, Yvonne Saenger… in Cancer Convergence (2017)

Article

Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination

Metastasis-competent circulating tumour cells (CTCs) experience oxidative stress in the bloodstream, but their survival mechanisms are not well defined. Here, comparing single-cell RNA-Seq profiles of CTCs fro...

Yu Zheng, David T. Miyamoto, Ben S. Wittner, James P. Sullivan… in Nature Communications (2017)