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Article
Open AccessAssociation Between Natural Hair Color, Race, and Alopecia
Limited epidemiologic data has suggested direct associations between hair pigment, race, and incidence of alopecia areata (AA). Here, we examine the relationship between natural hair color, race, and the lifet...
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Article
B-cell-specific checkpoint molecules that regulate anti-tumour immunity
The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cy...
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Article
Open AccessSpatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape
Spatiotemporal regulation of the cellular transcriptome is crucial for proper protein expression and cellular function. However, the intricate subcellular dynamics of RNA remain obscured due to the limitations...
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Article
Open AccessSalvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions
Glucose is vital for life, serving as both a source of energy and carbon building block for growth. When glucose is limiting, alternative nutrients must be harnessed. To identify mechanisms by which cells can ...
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Article
Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma
Systemic therapy for metastatic clear cell sarcoma (CCS) bearing EWSR1-CREB1/ATF1 fusions remains an unmet clinical need in children, adolescents, and young adults.
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Article
Targeting TBK1 to overcome resistance to cancer immunotherapy
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are lacking1,2. Here we identify the innate immune kinase TANK-bin...
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Article
A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy
Microphthalmia transcription factor (MITF) regulates melanocyte development and is the “lineage-specific survival” oncogene of melanoma. MITF is essential for melanoma initiation, progression, and relapse and has...
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Article
Open AccessMelanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease
Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD). We previously showed that MC1R signaling can facilitate n...
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Article
Author Correction: From genes to drugs: targeted strategies for melanoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Reference Work Entry In depth
Biology of Melanocytes and Primary Melanoma
Melanocytes make up only a tiny proportion of the skin cellular milieu but have a major impact on skin appearance as well as skin cancer risk by modulating skin pigmentation. Cutaneous melanocytes are derived ...
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Article
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells
Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs)1,2, but so far there has been little scientific validation of this link. Here we report that, ...
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Article
Open AccessDestabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
Most targeted cancer therapies fail to achieve complete tumor regressions or attain durable remissions. To understand why these treatments fail to induce robust cytotoxic responses despite appropriately target...
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Article
Cell-state dynamics and therapeutic resistance in melanoma from the perspective of MITF and IFNγ pathways
Targeted therapy and immunotherapy have greatly improved the prognosis of patients with metastatic melanoma, but resistance to these therapeutic modalities limits the percentage of patients with long-lasting r...
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Article
Open AccessLineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair
The melanocytic lineage, which is prominently exposed to ultraviolet radiation (UVR) and radiation-independent oxidative damage, requires specific DNA-damage response mechanisms to maintain genomic and transcr...
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Living Reference Work Entry In depth
Biology of Melanocytes and Primary Melanoma
Melanocytes make up only a tiny proportion of the skin cellular milieu but have a major impact on skin appearance as well as skin cancer risk by modulating skin pigmentation. Cutaneous melanocytes are derived ...
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Reference Work Entry In depth
The Biology of Pigmentation
Having roots in the earliest Mendelian experiments, the scientific examination of pigmentation offers the unique opportunity to better understand the contributions of genetics, signaling pathways, hormones, an...
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Article
Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche
Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour1,2. The location of this niche varies across species, but the evoluti...
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Living Reference Work Entry In depth
The Biology of Pigmentation
Having roots in the earliest Mendelian experiments, the scientific examination of pigmentation offers the unique opportunity to better understand the contributions of genetics, signaling pathways, hormones, an...
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Article
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are needed. Here we use a pooled in vivo genetic screening appr...
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Chapter
Transcriptional Regulation in Melanoma
Melanoma is one of the most chemo-resistant cancers and one whose incidence is increasing significantly. Transcription factors are DNA-binding proteins which control gene expression through recognition of spec...
