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  1. Article

    Open Access

    Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice

    Netrin-1 functions largely via combined receptors and downstream effectors. Evidence has shown that astrocytes express netrin-1 receptors, including DCC and UNC5H2. However, whether netrin-1 influences the fun...

    **aosong He, Yanqun Liu, **aohong Lin, Falei Yuan… in Journal of Neuroinflammation (2018)

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  2. No Access

    Article

    Synthesis of nanostructured barium phosphate and its application in micro-computed tomography of mouse brain vessels in ex vivo

    Micro-computed tomography (micro-CT) is a powerful tool for visualizing the vascular systems of tissues, organs, or entire small animals. Vascular contrast agents play a vital role in micro-CT imaging in order...

    Bangshang Zhu, Falei Yuan, **aoya Yuan, Yang Bo… in Journal of Nanoparticle Research (2014)

  3. No Access

    Article

    Biophysical regulation of epigenetic state and cell reprogramming

    Biochemical factors can help reprogram somatic cells into pluripotent stem cells, yet the role of biophysical factors during reprogramming is unknown. Here, we show that biophysical cues, in the form of parall...

    Timothy L. Downing, Jennifer Soto, Constant Morez, Timothee Houssin… in Nature Materials (2013)

  4. No Access

    Article

    Differentiation of multipotent vascular stem cells contributes to vascular diseases

    It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases. Here ...

    Zhenyu Tang, Aijun Wang, Falei Yuan, Zhiqiang Yan, Bo Liu… in Nature Communications (2012)

  5. No Access

    Article

    Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion

    Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular networ...

    Haiyan Lu, Yongting Wang, Falei Yuan, Jianrong Liu, Lili Zeng… in Frontiers of Medicine (2011)

  6. No Access

    Protocol

    Adeno-Associated Virus Mediated Gene Therapy in Ischemic Stroke

    Gene therapy offers a novel approach for the treatment of experimental stroke. The adeno-associated virus (AAV) mediated vascular endothelial growth factor (VEGF) gene transfer into the ischemic brain is descr...

    Yongting Wang, Falei Yuan, Guo-Yuan Yang in Drug Delivery to the Central Nervous System (2010)