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Article
Transient nuclear deformation primes epigenetic state and promotes cell reprogramming
Cell reprogramming has wide applications in tissue regeneration, disease modelling and personalized medicine. In addition to biochemical cues, mechanical forces also contribute to the modulation of the epigene...
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Article
Open AccessIntramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury
Muscle denervation from trauma and motor neuron disease causes disabling morbidities. A limiting step in functional recovery is the regeneration of neuromuscular junctions (NMJs) for reinnervation. Stem cells ...
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Article
Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro
Muscle loss and impairment resulting from traumatic injury can be alleviated by therapies using muscle stem cells. However, collecting sufficient numbers of autologous myogenic stem cells and expanding them ef...
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Article
Biophysical regulation of epigenetic state and cell reprogramming
Biochemical factors can help reprogram somatic cells into pluripotent stem cells, yet the role of biophysical factors during reprogramming is unknown. Here, we show that biophysical cues, in the form of parall...
