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Article
Open AccessAnti-inflammatory role of GM1 and other gangliosides on microglia
Gangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects in the ganglioside biosynthetic pathw...
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Article
Open AccessThe Canadian prospective cohort study to understand progression in multiple sclerosis (CanProCo): rationale, aims, and study design
Neurological disability progression occurs across the spectrum of people living with multiple sclerosis (MS). Although there are a handful of disease-modifying treatments approved for use in progressive phenot...
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Article
Open AccessAuthor Correction: Repression of phagocytosis by human CD33 is not conserved with mouse CD33
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessRepression of phagocytosis by human CD33 is not conserved with mouse CD33
CD33 is an immunomodulatory receptor linked to Alzheimer’s disease (AD) susceptibility via regulation of phagocytosis in microglia. Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include...
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Article
Open AccessRab32 connects ER stress to mitochondrial defects in multiple sclerosis
Endoplasmic reticulum (ER) stress is a hallmark of neurodegenerative diseases such as multiple sclerosis (MS). However, this physiological mechanism has multiple manifestations that range from impaired clearan...
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Article
Open AccessGranzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo
Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system (CNS). It is widely accepted that inflammatory cells play major roles in the pathogenesis of MS...
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Article
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
TH17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) i....
