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  1. Article

    Open Access

    Sorafenib and irinotecan (NEXIRI) as second- or later-line treatment for patients with metastatic colorectal cancer and KRAS-mutated tumours: a multicentre Phase I/II trial

    This trial evaluated the feasibility and efficacy of combined sorafenib and irinotecan (NEXIRI) as second- or later-line treatment of patients with KRAS-mutated metastatic colorectal cancer (mCRC), who had progre...

    E Samalin, O Bouché, S Thézenas, E Francois, A Adenis… in British Journal of Cancer (2014)

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  2. No Access

    Article

    Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases

    To assess the rate of R0 resection of liver metastases achieved after chemotherapy with FOLFIRINOX.

    M. Ychou, F. Viret, A. Kramar, F. Desseigne… in Cancer Chemotherapy and Pharmacology (2008)

  3. Article

    Open Access

    Phase II study of UFT with leucovorin and irinotecan (TEGAFIRI): first-line therapy for metastatic colorectal cancer

    This phase II trial was performed to evaluate the efficacy and tolerability of oral tegafur–uracil (UFT®) with leucovorin (LV) combined with intravenous (i.v.) irinotecan every 3 weeks (TEGAFIRI) as first-line tr...

    J-P Delord, J Bennouna, P Artru, H Perrier, F Husseini… in British Journal of Cancer (2007)

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  4. No Access

    Article

    High-dose, single-agent irinotecan as first-line therapy in the treatment of metastatic colorectal cancer

    Abstract

    M. Ychou, J. Raoul, F. Desseigne, C. Borel… in Cancer Chemotherapy and Pharmacology (2002)

  5. No Access

    Article

    Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer

    Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome characterized by familial predisposition to colorectal carcinoma and extracolonic cancers of the gastrointestinal, urological, and female reprodu...

    Q. Wang, C. Lasset, F. Desseigne, J.-C. Saurin, C. Maugard, C. Navarro… in Human Genetics (1999)