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Article
Open AccessValidity of age estimation methods and reproducibility of bone/dental maturity indices for chronological age estimation: a systematic review and meta-analysis of validation studies
Several approaches have been developed to estimate age, an important aspect of forensics and orthodontics, using different measures and radiological examinations. Here, through meta-analysis, we determined the...
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Article
Open AccessAxial and rotational alignment of lower limb in a Caucasian aged non-arthritic cohort
The alignment of human lower limb has been an area of ongoing study for decades. The purpose of this study was to analyze the axial and rotational alignment from hip to ankle in a Caucasian aged non-arthritic ...
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Article
Open AccessRisk of atrial fibrillation among bisphosphonate users: a multicenter, population-based, Italian study
Bisphosphonate treatment is used to prevent bone fractures. A controversial association of bisphosphonate use and risk of atrial fibrillation has been reported. In our study, current alendronate users were ass...
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Article
Health-related quality of life and treatment preferences in adolescents with type 1 diabetes. The VIPKIDS study
A multi-centre, observational, cross-sectional study was carried out to determine whether the health-related quality of life (HRQOL) of adolescents with type 1 diabetes is affected by different insulin treatme...
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Article
Assessing the risk of osteonecrosis of the jaw due to bisphosphonate therapy in the secondary prevention of osteoporotic fractures
There is evidence that the use oral bisphosphonates can lead to osteronecrosis of the jaws (ONJ). Although the occurrence of ONJ appears rare among oral bisphosphonates (BPs) users, it is important to know tha...
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Article
Information to cancer patients: a questionnaire survey in three different geographical areas in Italy
The way to inform cancer patients varies widely among different countries. In most Mediterranean countries, the traditional approach has been of partial disclosure of the truth. The intent of our work was to f...
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Article
Distress and Family Functioning in Oncogenetic Counselling for Hereditary and Familial Breast and/or Ovarian Cancers
We conducted a psychological assessment during oncogenetic counseling for hereditary breast/ovarian cancer. Anxiety and depression were assessed with the HAD scale, and family functioning and satisfaction with...
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Article
What do Italians at high risk of stroke know about ischaemic stroke? A survey among a group of subjects undergoing neuro-sonographic examination
The objective was to assess the knowledge about ischaemic stroke among selected groups of persons at high risk for stroke. Outpatients referred to 3 hospital ultrasound departments in the Marche Region (Italy)...
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Article
Open AccessCarboplatin, doxorubicin and etoposide in the treatment of tumours of unknown primary site
The aim of this study was to assess the activity and toxicity of a platinum-based treatment on a group of patients with unknown primary tumours (UPTs). Patients with a diagnosis of UPT underwent a standard dia...
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Article
Aldosterone synthase alleles and cardiovascular phenotype in young adults
The C(−344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/phen...
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Article
Large incidence variation of Type I diabetes in central-southern Italy 1990–1995: lower risk in rural areas
Aims/hypothesis. To evaluate the relation between the incidence of childhood Type I (insulin-dependent) diabetes mellitus and the degree of urbanization in the central-southern part of Italy. Met...
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Article
Calcium metabolism in adolescents and young adults with type 1 diabetes mellitus without and with persistent microalbuminuria
Alterations in calcium metabolism can be demonstrated in the course of insulin-dependent diabetes mellitus. In order to clarify if the presence of persistent microalbuminuria (MA) can affect the main parameter...
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Article
A randomized, controlled, clinical study of laparoscopic vs open tension-free inguinal hernia repair
Background: The aim of this prospective, randomized, controlled clinical study was to compare laparoscopic transabdominal preperitoneal (TAPP) hernia repair with a standard tension-free open mesh repair (open).
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Article
A phase II randomised trial of 5-fluorouracil with or without interferon alpha-2a in advanced colorectal cancer
With the association of 5-fluorouracil (5-FU) and alpha-interferon (IFN), objective responses as high as 26 63% have been reported in untreated patients with advanced colorectal cancer. However, grade 3-4 toxi...
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Article
Syphilis and blood donors: Comparison of two different diagnostic strategies
In this study the validity of the methods provided for by Italian law (VDRL or RPR tests) were compared with the diagnostic strategy suggested by WHO (the use of VDRL and TPHA tests in parallel). Sensitivity, ...
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Article
Interaction between alcohol consumption and positivity for antibodies to hepatitis C virus on the risk of liver cirrhosis: A case-control study
To assess the risk of develo** liver cirrhosis associated with alcohol consumption, HBV and HCV infection markers, we carried out a case-control study involving 115 patients admitted to the medical departmen...
