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Article
Open AccessCapacity Building in Sub-Saharan Africa as Part of the INTENSE-TBM Project During the COVID-19 Pandemic
Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), with at least 100,000 cases per year and a mortality rate of up to 50% in individuals co-infected with human immunodefic...
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Article
Open AccessIrinotecan and its metabolite SN38 inhibits procollagen I production of dermal fibroblasts from Systemic Sclerosis patients
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by a microangiopathy and fibrosis of the skin and internal organs. No treatment has been proved to be efficient in case of ...
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Article
Experimental and numerical investigation of key microstructural features influencing the localization of plastic deformation in Fe-TiB2 metal matrix composite
A new generation of iron-based matrix composite reinforced by TiB2 particles was deformed in tension to investigate at a mesoscopic scale the localization of plastic deformation in relation with characteristic mi...
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Article
Open AccessEvolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort
The objective of the study was to describe the evolution of chronic non-AIDS related diseases and their risk factors, in patients living with HIV (PLHIV) in the French ANRS CO3 Aquitaine prospective cohort, ob...
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Article
Open AccessParticle interspacing effects on the mechanical behavior of a Fe–TiB2 metal matrix composite using FFT-based mesoscopic field dislocation mechanics
This paper presents an application to metal matrix composites (MMCs) of an enhanced elasto-viscoplastic Fast Fourier Transform (EVP-FFT) formulation coupled with a phenomenological continuum Mesoscale Field Di...
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Article
Mutations in SUFU and PTCH1 genes may cause different cutaneous cancer predisposition syndromes: similar, but not the same
Many cancer predisposition syndromes are preceded or accompanied by a range of typical skin signs. Gorlin syndrome is a rare multisystem inherited disorder which can predispose to basal cell carcinomas (BCCs),...
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Article
Préparation colique et anesthésie générale : position commune Sfed/Sfar
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Article
Open Access“Daily life of CAPS patients treated with canakinumab (Ilaris®) : data from the French observational study - ENVOL Study”
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Article
Experimental Determination of Solid-Liquid Equilibria with Reactive Components: Example of the Fe-Ti-B Ternary System
A deep knowledge of phase relationships involving a liquid phase is of critical interest in solidification process. If chemically active elements are involved, the conditions under which phase equilibria will ...
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Chapter
Perioperative Strategy for Prevention of Chronic Postsurgical Pain: General Foundations
Opiates have a role in causing postoperative hyperalgesia. Postoperative hyperalgesia is probably involved in the causation of chronic postsurgical pain. Antihyperalgesic agents could reduce the incidence of c...
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Article
Critical Behavior of the Liquid Gas Transition of 4He Confined in a Silica Aerogel
We have studied 4He confined in a 95 % porosity silica aerogel in the vicinity of the bulk liquid gas critical point. Both thermodynamic measurements and light scattering experiments were performed to probe the e...
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Chapter
Stratégie péri-opératoire de prévention des douleurs chroniques post-chirurgicales : bases générales
La survenue de douleurs chroniques après chirurgie (DCPC) est un phénomène maintenant reconnu dont la réalité et l’ampleur ont été mises en évidence par de nombreuses études épidémiologiques. La persistance de...
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Article
Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women
Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes with a stronger effect in women. As the underlying mechanisms remain poorly characterised, we investigated its relationship wit...
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Article
Rare germline large rearrangements in the BRCA1/2 genes and eight candidate genes in 472 patients with breast cancer predisposition
Hereditary breast cancers account for up to 5–10 % of breast cancers and a majority are related to the BRCA1 and BRCA2 genes. However, many families with breast cancer predisposition do not carry any known mutati...
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Article
Open AccessA refined molecular taxonomy of breast cancer
The current histoclinical breast cancer classification is simple but imprecise. Several molecular classifications of breast cancers based on expression profiling have been proposed as alternatives. However, th...
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Article
On the Efficiency of Infrared Filters in Optical Cryostats
In an optical cryostat, the sample temperature is limited by the 300 K thermal radiation transmitted through the observation windows. As discussed in this paper, the corresponding heat load should be brought m...
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Chapter and Conference Paper
Weldability and Toughness Evaluation of the Ceramic Reinforced Steel Matrix Composites (TIB2-RSMC)
The general idea of this paper is to produce TiB2 (ceramic particles) reinforced steel matrix composites. These ceramic particles are the best reinforcements for steel matrix composites because of their high ther...
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Chapter and Conference Paper
Damage Analysis of the Ceramic Reinforced Steel Matrix Composites Sheets: Experimental and Numerical Study
This paper reports damage analysis of TiB2 (ceramic particles) reinforced steel matrix composite sheets. This new steel composite receives much attention as potential structural materials due to their high spe...
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Article
Risk factors for incident type 2 diabetes in individuals with a BMI of <27 kg/m2: the role of γ-glutamyltransferase. Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
Risk factors for incident type 2 diabetes, in particular, hepatic markers, have rarely been studied in leaner individuals. We aimed to identify the metabolic and hepatic markers associated with incident diabet...
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Chapter
Les principaux agents et techniques d’analgésie par voie systémique
À ce jour, aucun agent ne possède toutes les qualités requises (bonne tolérance hémodynamique et respiratoire, absence d’accumulation dans l’organisme, amnésie, anxiolyse) pour assurer une sédation et une anal...
