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  1. No Access

    Article

    Flow cytometric immunobead assay for the detection of BCR–ABL fusion proteins in leukemia patients

    BCR–ABL fusion proteins show increased signaling through their ABL tyrosine kinase domain, which can be blocked by specific inhibitors, thereby providing effective treatment. This makes detection of BCR–ABL aberr...

    F Weerkamp, E Dekking, Y Y Ng, V H J van der Velden, H Wai, S Böttcher… in Leukemia (2009)

  2. No Access

    Article

    Ectopic retroviral expression of LMO2, but not IL2Rγ, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy

    The occurrence of leukemia in a gene therapy trial for SCID-X1 has highlighted insertional mutagenesis as an adverse effect. Although retroviral integration near the T-cell acute lymphoblastic leukemia (T-ALL)...

    K Pike-Overzet, D de Ridder, F Weerkamp, M R M Baert, M M A Verstegen… in Leukemia (2007)

  3. No Access

    Article

    Identification of Notch target genes in uncommitted T-cell progenitors: no direct induction of a T-cell specific gene program

    Deregulated Notch signaling occurs in the majority of human T-ALL. During normal lymphoid development, activation of the Notch signaling pathway poses a T-cell fate on hematopoietic progenitors. However, the t...

    F Weerkamp, T C Luis, B A E Naber, E E L Koster, L Jeannotte, J J M van Dongen… in Leukemia (2006)

  4. No Access

    Article

    Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia

    Many acute lymphoblastic leukemias can be considered as malignant counterparts of cells in the various stages of normal lymphoid development in bone marrow and thymus. T-cell development in the thymus is an or...

    F Weerkamp, J J M van Dongen, F J T Staal in Leukemia (2006)

  5. No Access

    Article

    Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development

    Class I homeobox (HOX) genes comprise a large family of transcription factors that have been implicated in normal and malignant hematopoiesis. However, data on their expression or function during T-cell develo...

    T Taghon, K Thys, M De Smedt, F Weerkamp, F J T Staal, J Plum, G Leclercq in Leukemia (2003)