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  1. Article

    Open Access

    Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas

    Alternative Lengthening of Telomeres (ALT) is a telomere maintenance pathway utilised in 15% of cancers. ALT cancers are strongly associated with inactivating mutations in ATRX; yet loss of ATRX alone is insuffic...

    M. Udugama, L. Hii, A. Garvie, M. Cervini, B. Vinod, F.-L. Chan… in Nature Communications (2021)

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  2. Article

    Open Access

    Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial–mesenchymal transition and remodeling of actin cytoskeleton organization

    The cancer cells can acquire migration and invasion capacities during the metastasis process through the developmental regulatory program epithelial–mesenchymal-transition (EMT), and through its reverse proces...

    G Cai, D Wu, Z Wang, Z Xu, K-B Wong, C-F Ng, F L Chan, S Yu in Oncogene (2017)

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  3. No Access

    Article

    Orphan nuclear receptor estrogen-related receptor-β suppresses in vitro and in vivo growth of prostate cancer cells via p21WAF1/CIP1 induction and as a potential therapeutic target in prostate cancer

    Recent studies indicate that estrogen-related receptors (ERRs) are involved in similar estrogen receptor (ER) regulatory pathways and play roles in energy and lipid metabolism. Here, we analysed the functional...

    S Yu, Y C Wong, X H Wang, M T Ling, C F Ng, S Chen, F L Chan in Oncogene (2008)

  4. No Access

    Article

    Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model

    To date, only a few prostate-specific vector genes have been tested for prostate targeting in gene therapy of prostate cancer (CaP). Current clinical trials of gene therapy of CaP utilize the only two availabl...

    M Y Gabril, T Onita, P G Ji, H Sakai, F L Chan, J Koropatnick, J L Chin… in Gene Therapy (2002)

  5. No Access

    Article

    H-type tracheo-oesophageal fistula: appearance on three-dimensional computed tomography and virtual bronchoscopy

    H-type tracheo-oesophageal fistula (TOF) is a rare type of fistula without oesophageal atresia. The symptoms are usually present at birth, but the diagnosis is often delayed. Traditionally, contrast oesophago...

    S. D. V. Le, W. W. M. Lam, P. K. H. Tam, W. Cheng… in Pediatric Surgery International (2001)

  6. No Access

    Article

    Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions

    Quaternary ammonium ions are common pharmacological probes used to study the kinetic properties of K+ channels in smooth muscle cells. On the other hand, some ammonium compounds cause vasorelaxation through unkn...

    Yu Huang, X.Q. Yao, F.L. Chan, C.W. Lau… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2000)

  7. No Access

    Article

    Glycoconjugates of the Rat Ciliary Body Epithelium: A Lectin Histochemical and Protein Blotting Study

    The present study sought to identify and partially characterize the glycoconjugates specific to the double-layered ciliary body epithelium of the rat eye by lectin histochemistry and lectin blottings. Hydrated...

    F.L. Chan, H.K. Poon, Y. Huang, H.L. Choi in The Histochemical Journal (1999)

  8. No Access

    Article

    Renal metastasis from choriocarcinoma: MRI appearance

    Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. It grows rapidly and metastasizes to the lung, liver, and, less frequently, to the brain. Renal involvement is rare. Magneti...

    K. S. Tai, F. L. Chan, H. Y. S. Ngan in Abdominal Imaging (1998)

  9. No Access

    Article

    Hyaluronan and chondroitin sulfate proteoglycans are colocalized to the ciliary zonule of the rat eye: a histochemical and immunocytochemical study

     In previous studies, chondroitin sulfate proteoglycans have been localized to the periphery of the zonular fibers and the individual zonular fibrils (or microfibrils) after Cuprolinic blue staining in conjunc...

    F. L. Chan, H. L. Choi, C. B. Underhill in Histochemistry and Cell Biology (1997)

  10. No Access

    Article

    Paediatric thymoma: Unusual occurrence in two siblings

    Invasive cystic thymoma is reported in two siblings (an 11-year-old girl and a 9-year-old boy) and the radiographic, CT and ultrasonographic features are described. The tumours were removed by thoracotomy. Fam...

    W. W. M. Lam, F. L. Chan, Y. L. Lau, M. T. Chau, C. K. Mok in Pediatric Radiology (1993)

  11. No Access

    Article

    Dystrophic intracranial calcification: CT evidence of ‘cerebral steal’ from arteriovenous malformation

    Two cases of dystrophic intracranial calcification due to arteriovenous malformations (AVM) are reported. The characteristic distribution is in the watershed areas and away from the AVM. Deposition of calcium ...

    Y. L. Yu, E. K. W. Chiu, E. Woo, F. L. Chan, W. K. Lam, C. Y. Huang… in Neuroradiology (1987)

  12. No Access

    Article

    Bulbar palsy aggravated by metrizamide CT cisternography

    E. Woo, F. L. Chan, Y. L. Yu, C. Y. Huang, C. M. Chang, P. K. Lee… in Neuroradiology (1987)

  13. No Access

    Article

    Diagnosis and evaluation of esophageal atresia by direct sagittal CT

    Direct sagittal CT is possible in newborns because of their small body-size. With this noninvasive investigation, we were able to establish a correct diagnosis in two neonates with esophageal atresia. Moreover...

    P. K. H. Tam, F. L. Chan, H. Saing in Pediatric Radiology (1987)

  14. No Access

    Article

    Detection of mercuric cyanide and alkali halides in presence of alkali cyanide

    F. Feigl, F. L. Chan in Microchimica Acta (1967)