-
Article
Stochastic modelling of apoptosis kinetics
Robust quantitative estimation of average whole cell mitochondrial dysfunction is a useful tool for assessing sensitivity to apoptotic stimuli induced either by novel agents, or following manipulation of apopt...
-
Article
Open AccessBcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species
Resistance to apoptosis is a major obstacle preventing effective therapy for malignancy. Mitochondria localized anti-death proteins of the Bcl-2 family play a central role in inhibiting apoptosis and therefore...
-
Chapter and Conference Paper
Simultaneous Presentation of B- and T-Cell Malignant Lymphoma
Multiclonal NHL of the B-cell type has been described [1, 2], most often when two histological types of lymphoma have been noted in simultaneous or successive biopsies. This occurs predominantly when follicula...