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  1. No Access

    Article

    Stochastic modelling of apoptosis kinetics

    Robust quantitative estimation of average whole cell mitochondrial dysfunction is a useful tool for assessing sensitivity to apoptotic stimuli induced either by novel agents, or following manipulation of apopt...

    D. A. Fennell MD PhD, A. Pallaska, M. Corbo, F. E. Cotter in Apoptosis (2005)

  2. Article

    Open Access

    Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species

    Resistance to apoptosis is a major obstacle preventing effective therapy for malignancy. Mitochondria localized anti-death proteins of the Bcl-2 family play a central role in inhibiting apoptosis and therefore...

    D A Fennell, M Corbo, A Pallaska, F E Cotter in British Journal of Cancer (2001)

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