-
Article
Association of Plasma Selenium and Its Untargeted Metabolomic Profiling with Cervical Cancer Prognosis
Selenium is an essential trace element that shows beneficial or adverse health effects depending on the dose. However, its role in the prognosis of cervical cancer (CC) has been less reported. We aimed to expl...
-
Article
Open AccessSex-dependent dysregulation of human neutrophil responses by bisphenol A
In the present study, we aimed to investigate selected functions of human neutrophils exposed to bisphenol A (BPA) under in vitro conditions. As BPA is classified among xenoestrogens, we compared its action an...
-
Article
Open AccessSYK inhibition targets acute myeloid leukemia stem cells by blocking their oxidative metabolism
Spleen tyrosine kinase (SYK) is an important oncogene and signaling mediator activated by cell surface receptors crucial for acute myeloid leukemia (AML) maintenance and progression. Genetic or pharmacologic i...
-
Article
Open AccessA Proliferation-Inducing Ligand Regulation in Polymorphonuclear Neutrophils by Panax ginseng
A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor superfamily that was first identified as a factor favoring tumorigenesis. APRIL is important fitness and survival factors for B ...
-
Article
Open AccessEffect of bisphenol A on human neutrophils immunophenotype
Neutrophils (PMN) play a key role in eliciting congenital immune response. These cells are equipped with specific receptors that are located on the surface of their cell membrane. These receptors produce vario...
-
Article
Open AccessEffect of Arsenic Exposure on NRF2-KEAP1 Pathway and Epigenetic Modification
Arsenic (As) is a known toxic element and carcinogen. Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular adaptation to oxidants and electrophiles by inducing antioxidant ...
-
Article
Open AccessLipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1
Since targeting oxidative stress markers has been recently recognized as a novel therapeutic target in cancer, it is interesting to investigate whether genetic susceptibility may modify oxidative stress respon...
-
Article
Open AccessSelenium and cancer – what have we learned from epidemiology and molecular epidemiology studies?
-
Article
Open AccessMatrix metalloproteinases and genetic mouse models in cancer research: a mini-review
Carcinogenesis is a multistep and also a multifactorial process that involves agents like genetic and environmental factors. Matrix metalloproteinases (MMPs) are major proteolytic enzymes which are involved in...
-
Article
Open AccessDevelopment of Asthmatic Response upon Bronchial Allergen Challenge Is Associated with Dynamic Changes of Interleukin-10-Producing and Interleukin-10-Responding CD4+ T Cells
The role of adaptive immune system in regulation of asthmatic responses remains elusive. Here, we performed a comprehensive time-course analysis of mutual relationships between development of asthmatic respons...
-
Article
Open AccessPolymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients
NRF2 transcription factor is involved in modulation of various antioxidant and metabolic genes and, therefore, may modulate anti-carcinogenic potential. Association between polymorphisms of NRF2 and five NRF2-reg...
-
Article
Open AccessLevels of biological markers of nitric oxide in serum of patients with squamous cell carcinoma of the oral cavity
The aim of the study was a determination of the levels of nitric oxide (NO) and its biological markers such as malonyldialdehyde (MDA) and nitrotyrosine in the serum of patients with squamous cell carcinoma (S...
-
Article
Open AccessRelevance of selenoprotein transcripts for selenium status in humans
The most commonly used methods for assessing the selenium (Se) status in humans involve analysis of Se concentration, selenoprotein activity, and concentration in the blood and its compartments. Recently, it h...
-
Article
Open AccessThe Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils
In the present study we examined a role of pro-apoptotic Bax and anti-apoptotic Mcl-1 proteins, participating in the regulation of intrinsic apoptosis pathway in human neutrophils (PMNs) exposed to N-nitrosodimet...
-
Article
Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism
Selenium (Se) is a trace element suggested to act chemopreventive in lung cancer. The mechanism by which Se suppresses tumour development may be associated with some of the functions of selenoproteins, includi...
-
Article
Serum Levels of IL-lβ, IL-6, TNF-α, sTNF-RI and CRP in Patients with oral cavity cancer
Pro-inflammatory cytokines, such as interleukin-lβ (IL-lβ), interleukin-6 (IL-6) and tumor necrosis factor- (TNF-α) play an essential role in the regulation of immune response to, and may have prognostic signi...
