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Article
Open AccessThe association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density
Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of bre...
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Article
Open AccessMammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical and screening applications; however, MD measurements are influenced by mammography modality (screen film/di...
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Article
Open AccessFemale chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) an...
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Article
Open AccessLipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1
Since targeting oxidative stress markers has been recently recognized as a novel therapeutic target in cancer, it is interesting to investigate whether genetic susceptibility may modify oxidative stress respon...
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Article
Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland
Concerns regarding a possible link between bisphenol A (BPA) and breast cancer have been mounting, but studies in human populations are lacking. We evaluated the association between the major urinary BPA metab...
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Article
Prolactin Receptor Expression and Breast Cancer: Relationships with Tumor Characteristics among Pre- and Post-menopausal Women in a Population-Based Case–Control Study from Poland
Previous studies have found an association between elevated circulating prolactin levels and increased risk of breast cancer. Prolactin stimulates breast cancer cell proliferation, migration, and survival via ...
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Article
Open AccessRelationship between intensity of night shift work and antioxidant status in blood of nurses
Light-at-night exposure can disrupt the human circadian rhythm via clock gene expressions. The circadian rhythm influences antioxidant enzymes’ activity and cellular mRNA levels of these enzymes. The employees...
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Article
Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancer
Molecular and morphological alterations related to carcinogenesis have been found in terminal duct lobular units (TDLUs), the microscopic structures from which most breast cancer precursors and cancers develop...
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Article
Accelerometer-based measures of active and sedentary behavior in relation to breast cancer risk
Epidemiologic studies suggest that physical activity reduces breast cancer risk by 20–40 %. However, prior studies have relied on measures of self-report. In a population-based case–control study, we evaluated...
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Article
Detectable clonal mosaicism and its relationship to aging and cancer
Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such ...
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Article
Open AccessAnalysis of terminal duct lobular unit involution in luminal A and basal breast cancers
Involution of terminal duct lobular units (TDLUs), the structures that give rise to most breast cancers, has been associated with reduced breast cancer risk. Data suggest that the etiology and pathogenesis of ...
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Article
Fine map** of 14q24.1 breast cancer susceptibility locus
In the National Cancer Institute Cancer Genetic Markers of Susceptibility (CGEMS) genome-wide association study of breast cancer, a single nucleotide polymorphism (SNP) marker, rs999737, in the 14q24.1 interva...
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Article
Open AccessGenetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland
Studies suggest that high circulating levels of prolactin increase breast cancer risk. It is unclear if genetic variations in prolactin (PRL) or prolactin receptor (PRLR) genes also play a role. Thus, we examined...
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Article
Open AccessAssociation between night shift work, melatonin and estradiol in nurses
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Article
Open AccessCircadian gene variants and MT6s level in nurses under different work shifts – preliminary results
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Article
Expression of TGF-β signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics
The transforming growth factor beta (TGF-β) pathway can play either a tumor-suppressing or a tumor-promoting role in human breast carcinogenesis. In order to determine whether expression of TGF-β signaling fac...
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Article
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2
Douglas Easton and colleagues report results of a large multistage genome-wide association study of breast cancer. The study identifies two new breast cancer risk loci on chromosomes 3p24 and 17q23.2.
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Article
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
David Hunter and colleagues report results of the CGEMS multistage genome-wide association study of breast cancer. They identify two new risk variants on chromosomes 1p11.2 and 14q24.1, and confirm several pre...
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Article
Genetic variation in CYP17 and endometrial cancer risk
Genetic variation in CYP17 is suspected to be related to endometrial cancer risk based on its role in the regulation of steroid and non-steroid hormone biosynthesis. Reported associations between CYP17 and higher...
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Article
Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status
The inconsistent associations between fruit and vegetable intake and breast cancer risk may be due to heterogeneity of associations by estrogen (ER) and progesterone receptor (PR) status of the tumors. We eval...
