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Article
Pharmacokinetics of Levodopa and Carbidopa in Rats Following Different Routes of Administration
This study examined the pharmacokinetics of levodopa and carbidopa in the rat after different modes of administration. The drugs were given simultaneously by the intravenous, intraarterial, oral, duodenal, and...
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Article
Altered Pharmacokinetics and Dynamics of Apomorphine in the Malnourished Rat: Modeling of the Composed Relationship Between Concentration and Heart-Rate Response
The impact of malnutrition on the pharmacokinetics and pharmacodynamics (change in heart rate) of apomorphine was studied in the rat. One group of rats received a low-protein diet (0.5%) ad libitum to produce pre...