17 Result(s)
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Article
Open AccessTargeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma
Despite the development of new targeted and immune therapies, the prognosis of metastatic melanoma remains bleak. Therefore, it is critical to better understand the mechanisms controlling advanced melanoma to ...
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Article
Open AccessCholangiocarcinoma 2020: the next horizon in mechanisms and management
Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~...
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Chapter
Hepatic Progenitor Cells and Biliary Tree Stem Cells
In the adult human liver, hepatic stem/progenitor cells (HPCs) are facultative bipotential stem cells which reside in the canals of Hering and in bile ductules. HPCs have a unique phenotype and are capable to ...
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Chapter
Anatomy and Embryology of the Liver
This chapter deals in the first part with the anatomy of the liver, highlighting in particular the clinical anatomy and the relevant morphological aspects of practical interest to the physician, including the ...
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Chapter
Liver Histology
The basic histological structure of the liver consists of closely intertwined epithelial cell cords that make it a cordonal gland. The classic hepatic lobule with the portal spaces in the periphery and the cen...
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Article
Open AccessCholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Cholangiocarcinomas are a heterogeneous group of bile duct cancers and the second most common primary liver tumour worldwide. In this Consensus statement, the newly formed European Network for the Study of Cho...
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Article
Open AccessTransplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis
Efforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. In the ...
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Article
Nonalcoholic fatty liver disease and atherosclerosis
Atherosclerosis is a complex inflammatory disease comprising multiple plaque phenotypes. The development of advanced atheromatous plaques with necrotic core represents the result of the invasion of lipid pools...
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Article
The biliary tree—a reservoir of multipotent stem cells
This Perspectives describes the characteristics of stem and progenitor cells in the liver, biliary tree and pancreas. A hypothetical model of maturational cell lineages is presented, highlighting the common em...
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Chapter
Cholangiocarcinoma
The incidence and mortality of cholangiocarcinoma are increasing worldwide. Cholangiocarcinogenesis is a multistep process evolving from a normal condition through chronic inflammation of the biliary tract to ...
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Article
The fascial structures of the rectum and the “so-called mesorectum”: an anatomical or a terminological controversy?
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Article
Increased Proliferation and Apoptosis of Colonic Epithelial Cells in Dextran Sulfate Sodium-Induced Colitis in Rats
We have evaluated morphologic alterations and epithelial cell apoptosis and proliferation of colonic mucosa in the acute and chronic phases of DSS-induced colitis. Colitis was induced in Sprague-Dawley rats by...
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Article
Peyer's Patches Epithelium in the Rat
The epithelial layer covering lymphoid follicles of Peyer's patches consists of cells with a different surface morphology. Some of these cells have been described as a distinct cytotype, the so-called M cells....
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Article
Intestinal Microvascular Patterns During Hemorrhagic Shock
While injuries due to a hypoxic state commonly appear later in both intestinal crypts and basal portion of the villi than in the apical portion, a nonhomogeneous distribution of blood flow in the intestinal mu...
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Article
Dextran Sulfate Sodium (DSS) Colitis in Rats (Clinical, Structural, and Ultrastructural Aspects)
Aim of this study was to assess the structural,ultrastructural, immunohistochemical, and clinicalaspects in Sprague-Dawley rats with dextrane sulfatesodium (DSS)-induced colitis. Colitis was induced in Sprague...
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Article
Liver Metabolic Zonation and Hepatic Microcirculation in Carbon Tetrachloride-Induced Experimental Cirrhosis
The exact cause of the hepatic failure in livercirrhosis is currently unclear, and two main theorieshave been proposed: the first is based on the alteredhepatocyte function (sick hepatocyte hypothesis); the se...
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Chapter
Pericyte Topography of the Microvasculature of Skeletal Muscle: Correlated Analysis of Corrosion Casts and KOH-Digested Specimens
During the past few years, different approaches to the study of pericytes in the skeletal muscle microvasculature have been made through the use of different techniques, including corrosion casts.
