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Article
Open AccessMolecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver
Recent studies demonstrated reduced blood lysosomal acid lipase (LAL) activity in patients with nonalcoholic fatty liver disease (NAFLD). We aimed to verify hepatic LAL protein content and activity in in vitro...
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Article
Open AccessThe role of estrogen and progesterone receptors in the rotator cuff disease: a retrospective cohort study
Rotator cuff (RC) tears represent a common cause of shoulder pain and dysfunction in adults. The disease affects primarily women and occurs mainly in the postmenopausal period.
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Article
Open AccessFragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge
Intrahepatic cholangiocarcinoma (iCCA) is a rare malignancy of the intrahepatic biliary tract with a very poor prognosis. Although some clinicopathological parameters can be prognostic factors for iCCA, the mo...
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Article
Open AccessChronic MPTP in Mice Damage-specific Neuronal Phenotypes within Dorsal Laminae of the Spinal Cord
The neurotoxin 1-methyl, 4-phenyl, 1, 2, 3, 6-tetrahydropiridine (MPTP) is widely used to produce experimental parkinsonism. Such a disease is characterized by neuronal damage in multiple regions beyond the ni...
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Article
Open AccessCorrection: Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue
Since online publication of this article, the authors noticed that there was a basic citation error in PubMed citation data. Specifically, the name of the author “Piergiorgio La Rosa” is cited as "Rosa P” in t...
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Article
Open AccessFrataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue
Decreased expression of mitochondrial frataxin (FXN) causes Friedreich’s ataxia (FRDA), a neurodegenerative disease with type 2 diabetes (T2D) as severe comorbidity. Brown adipose tissue (BAT) is a mitochondri...
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Chapter
Hepatic Progenitor Cells and Biliary Tree Stem Cells
In the adult human liver, hepatic stem/progenitor cells (HPCs) are facultative bipotential stem cells which reside in the canals of Hering and in bile ductules. HPCs have a unique phenotype and are capable to ...
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Chapter
Challenges in Driving New Generations of Power Switches for Motor Drive: A dV/dt Self-Adjusting Architecture for Superjunction Power Devices
A dV/dt self-adjusting architecture for driving new generations of power transistors is presented. Superjunction technology provided a real opportunity to significantly improve the overall performance/cost rat...
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Chapter
Anatomy and Embryology of the Liver
This chapter deals in the first part with the anatomy of the liver, highlighting in particular the clinical anatomy and the relevant morphological aspects of practical interest to the physician, including the ...
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Chapter
Liver Histology
The basic histological structure of the liver consists of closely intertwined epithelial cell cords that make it a cordonal gland. The classic hepatic lobule with the portal spaces in the periphery and the cen...
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Article
Open AccessThe fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells
The fragile X mental retardation protein (FMRP) is lacking or mutated in patients with the fragile X syndrome (FXS), the most frequent form of inherited intellectual disability. FMRP affects metastasis formati...
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Article
Open AccessNo effects of oral vitamin D supplementation on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial
Non-alcoholic fatty liver disease (NAFLD) is the most common hepatic disorder worldwide, reaching prevalence up to 90 % in obese patients with type 2 diabetes (T2D), and representing an independent risk factor...
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Article
Upper GI endoscopy in elderly patients: predictive factors of relevant endoscopic findings
Elderly patients are at increased risk for peptic ulcer and cancer. Predictive factors of relevant endoscopic findings at upper endoscopy in the elderly are unknown. This was a post hoc analysis of a nationwid...
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Article
Helicobacter pylori management in non-steroidal anti-inflammatory drug therapy patients in primary care
Non-steroidal anti-inflammatory drugs (NSAIDs) may cause gastroduodenal ulcers and its complications. Helicobacter pylori infection is recognized as an additional risk factor for ulcer development, its eradicatio...
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Article
Open AccessStrong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes
Hypovitaminosis D has been recently recognized as a worldwide epidemic. Since vitamin D exerts significant metabolic activities, comprising free fatty acids (FFA) flux regulation from the periphery to the live...
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Article
Electrospun Hydroxyapatite-Functionalized PLLA Scaffold: Potential Applications in Sternal Bone Healing
Sternal synthesis after median sternotomy, a conventional access practice in thoracic and cardiac surgery, is at the basis of severe complications, often impairing the clinical outcome of surgical intervention...
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Article
Endoscopic management of failed colonoscopy in clinical practice: to change endoscopist, instrument, or both?
Caecal intubation fails up to 20% of colonoscopy in clinical practice. We aimed to assess whether (1) in patients with a prior incomplete colonoscopy with a standard adult colonoscope, a subsequent caecal intu...
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Article
Treatment of low-grade gastric MALT-lymphoma unresponsive to Helicobacter pylori therapy
The most favourable therapeutic strategy for gastric MALT-lymphoma not responding to Helicobacter pylori eradication still remains unclear, neither official guidelines nor randomised studies being available. We t...
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Article
Detection of colonic polyps according to insertion/withdrawal phases of colonoscopy
Issues on colonoscopy quality are crucial to reduce the advanced neoplasia miss rate of colonoscopy. Recently, a >6-min withdrawal time has been recommended. However, the relative prevalence of polyp detected ...
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Article
Helicobacter pylori vacA Arrangement and Related Diseases: A Retrospective Study Over a Period of 15 Years
Peptic ulcer disease incidence is decreasing. Both s1m1 and s1m2 vacA gene combinations of Helicobacter pylori have been associated with the development of major gastroduodenal diseases. This study assessed wheth...
