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Article
Safety of advanced laparoscopic hepatectomy for elderly patients: a Japanese nationwide analysis
Although basic laparoscopic hepatectomy (LH) has become the standard procedure for hepatectomy, the safety of advanced LH remains to be clarified, especially in elderly patients. We investigated the safety of ...
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Article
Occult bacteremia in living donor liver transplantation: a prospective observational study of recipients and donors
To investigate the incidence and clinical impact of occult bacteremia in liver transplantation (LT).
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Article
Open AccessMalignant perineurioma derived from the retroperitoneum with an aggressive clinical course: a case report
Malignant perineurioma is a rare malignant counterpart of perineurioma derived from perineural cells. Resection is the primary option for the treatment of malignant perineuriomas; however, patients often devel...
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Article
Feasible living donor liver transplantation for patients on chronic hemodialysis: a multicenter study in East Asian countries
End-stage liver and kidney disease is an indication for simultaneous liver and kidney transplantation. However, in countries where deceased donor transplantation is not well established, living donor liver tra...
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Article
Open AccessA multi-institutional randomized phase III study comparing minimally invasive distal pancreatectomy versus open distal pancreatectomy for pancreatic cancer; Japan Clinical Oncology Group study JCOG2202 (LAPAN study)
Minimally invasive distal pancreatectomy (MIDP), including laparoscopic and robotic distal pancreatectomy, has gained widespread acceptance over the last decade owing to its favorable short-term outcomes. Howe...
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Article
Open AccessDownregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage
Osteoprotegerin (OPG) is a secreted cytokine that functions as a decoy receptor for receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL). Anti-RANKL treatment for bone metastasis has been widely ...
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Article
Acinar cystic transformation in the pancreatic tail
Pancreatic acinar cystic transformation (ACT) is a rare non-neoplastic cystic lesion that is predominantly located at the pancreatic head in females. Preoperative definitive diagnosis of ACT remains challengin...
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Article
Albumin-Bilirubin Score at Post-Hepatectomy Hepatocellular Carcinoma Recurrence: Impact on Survival and Association with Post-Hepatectomy Liver Failure
Our objective was to investigate the impact of albumin-bilirubin (ALBI) score at the time of post-hepatectomy hepatocellular carcinoma (HCC) recurrence on survival after recurrence (SAR). We further explored t...
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Article
Open AccessProtocol of the RACB study: a multicenter, single-arm, prospective study to evaluate the efficacy of resection of initially unresectable hepatocellular carcinoma with atezolizumab combined with bevacizumab
Although the standard therapy for advanced-stage hepatocellular carcinoma (HCC) is systemic chemotherapy, the combination of atezolizumab and bevacizumab (atezo + bev) with a high objective response rate may l...
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Article
Cadaver surgical training and research using donated cadavers in the field of surgery in Japan: an overview of reports from 2012 to 2021
Subsequent to the publication of “Guidelines for cadaver dissection in education and research of clinical medicine” in 2012, cadaver surgical training (CST) was implemented in various surgical fields across Ja...
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Article
Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. We previously reported that chromatin remodeler Brg1 is essential for acinar cell-derived PDAC formation in mice. However, the functional role ...
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Article
Impact of liver volumetric regeneration on survival outcomes in patients with hepatocellular carcinoma after major hepatectomy
Prognostic value of liver volumetric regeneration (LVR) in patients with hepatocellular carcinoma (HCC) who undergo major hepatectomy remains unknown. The aim of this study was to investigate the impact of LVR...
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Article
Laparoscopic Parenchyma-Sparing Resection of Difficult-to-Resect Deep Posterosuperior Liver Lesions: Conceptual Technique to Ensure Optimal Margin
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Article
Impact of the Intermittent Pringle Maneuver for Predicting Post-hepatectomy Liver Failure: A Cohort Study of 597 Consecutive Patients
Intermittent Pringle maneuver (PM) is widely performed to reduce blood loss during hepatectomy; however, its impact on clinically relevant post-hepatectomy liver failure (PHLF) remains controversial. This stud...
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Article
Open AccessCorrection: A Conceptual Classification of Resectability for Hepatocellular Carcinoma
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Open AccessA Conceptual Classification of Resectability for Hepatocellular Carcinoma
In the era of multidisciplinary treatment strategy, resectability for hepatocellular carcinoma (HCC) should be defined. This study aimed to propose and validate a resectability classification of HCC.
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Article
Open AccessPrimary hepatic extranodal marginal zone B-cell mucosa-associated lymphoid tissue lymphoma treated by laparoscopic partial hepatectomy: a case report
Primary hepatic extranodal marginal zone B-cell mucosa-associated lymphoid tissue (MALT) lymphoma is very rare, so it is difficult to diagnose preoperatively. And there is no established treatment for hepatic ...
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Development of a New Imaging System
In recent years, the development of intraoperative navigation using fluorescent dyes has progressed. Among the intraoperative navigation techniques, fluorescence imaging using ICG and a near-infrared camera sy...
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Article
Open AccessAcute coronary syndrome after liver transplantation in a young primary biliary cholangitis recipient with dyslipidemia: a case report
Primary biliary cholangitis (PBC) is a chronic, progressive liver disease associated with dyslipidemia. There is a consensus that PBC does not accelerate coronary artery disease despite high cholesterol levels...
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Article
Open AccessEstablishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer
Pancreatic cancer is one of the most lethal tumors. The aim of this study is to provide an effective therapeutic discovery platform for pancreatic cancer by establishing and characterizing patient-derived orga...
