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  1. No Access

    Article

    Identification and characterization of an alternative cancer-derived PD-L1 splice variant

    Therapeutic blockade of the PD-1/PD-L1 axis is recognized as an effective treatment for numerous cancer types. However, only a subset of patients respond to this treatment, warranting a greater understanding o...

    Nadia B. Hassounah, Venkat S. Malladi, Yi Huang… in Cancer Immunology, Immunotherapy (2019)

  2. Article

    Open Access

    Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

    Tumor orchestrated metabolic changes in the microenvironment limit generation of anti-tumor immune responses. Availability of arginine, a semi-essential amino acid, is critical for lymphocyte proliferation and...

    Juan J. Miret, Paul Kirschmeier, Shohei Koyama… in Journal for ImmunoTherapy of Cancer (2019)

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