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  1. No Access

    Article

    A kinase-cGAS cascade to synthesize a therapeutic STING activator

    The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this chal...

    John A. McIntosh, Zhijian Liu, Brian M. Andresen, Nastaran Salehi Marzijarani… in Nature (2022)

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    Article

    N-Glycosylamine-mediated isotope labeling for mass spectrometry-based quantitative analysis of N-linked glycans

    N-Linked glycosylation is a major protein modification involved in many essential cellular functions. Methods capable of quantitative glycan analysis are highly valuable and have been actively pu...

    Bing Gong, Erik Hoyt, Heather Lynaugh… in Analytical and Bioanalytical Chemistry (2013)

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    Protocol

    High-Throughput Multimodal Strong Anion Exchange Purification and N-Glycan Characterization of Endogenous Glycoprotein Expressed in Glycoengineered Pichia pastoris

    The secretory pathway of the yeast Pichia pastoris has been engineered to produce complex human-type N-glycans (Choi et al., Proc Natl Acad Sci USA 100:5022–5027, 2003; Hamilton et al., Science 301:1244–1246, 200...

    Sujatha Gomathinayagam, Erik Hoyt, Alissa M. Thompson, Eric Brown… in Therapeutic Proteins (2012)