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  1. Article

    Open Access

    TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence

    Cellular senescence is implicated in a great number of diseases including cancer. Although alterations in mitochondrial metabolism were reported as senescence drivers, the underlying mechanisms remain elusive....

    Valerio Farfariello, Dmitri V. Gordienko, Lina Mesilmany… in Nature Communications (2022)

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  2. Article

    Open Access

    Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways

    Although several anti-angiogenic therapies have been approved in the treatment of cancer, the survival benefits of such therapies are relatively modest. Discovering new molecules and/or better understating sig...

    Rodrigue Romon, Eric Adriaenssens, Chann Lagadec, Emmanuelle Germain… in Molecular Cancer (2010)

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  3. No Access

    Article

    Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

    Chromatin is a dynamic macromolecular structure epigenetically modified to regulate specific gene expression. Altered chromatin function can lead to aberrant expression of growth regulators and may, ultimately...

    Angela Nebbioso, Nicole Clarke, Emilie Voltz, Emmanuelle Germain… in Nature Medicine (2005)