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Article
Early and sustained improvement in fatigue-related quality of life following red blood cell transfusion in outpatients
Outpatients with hematologic disease often receive red cell transfusion to treat anemia and fatigue. The effect of transfusion on fatigue-related quality of life and how well this effect is sustained has not b...
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Article
Genetic analysis of metabolic defects in the spontaneously hypertensive rat
Abnormalities in carbohydrate and lipid metabolism are common in patients with essential hypertension and in the spontaneously hypertensive rat (SHR). To identify chromosome regions contributing to this clust...
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Article
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
The human insulin-resistance syndromes, type 2 diabetes, obesity, combined hyperlipidaemia and essential hypertension, are complex disorders whose genetic basis is unknown. The spontaneously hype...
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Article
Linkage of 11β-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat
In Dahl salt-hypertension sensitive (S) and resistant (R) strains fed a high NaCI diet, 11β-hydroxylase polymorphisms cosegregate with the adrenal capacity to synthesize 18-hydroxy-11-deoxycorticosterone (18-O...