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Article
Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis
The BCL-2 family of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1, can mediate survival of some types of cancer. DT2216 is a PROteolysis-TArgeting Chimera (PROTAC) that degrades BCL-XL specifically and is i...
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Protocol
In Vitro Reconstitutive Base Excision Repair (BER) Assay
The mammalian cell genome is continuously exposed to endogenous and exogenous insults that modify its DNA. These modifications can be single-base lesions, bulky DNA adducts, base dimers, base alkylation, cytos...
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Article
Tapanuli orangutan endangered by Sumatran hydropower scheme
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Article
Open AccessDNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
Fanconi anemia (FA) is a multigenic disease of bone marrow failure and cancer susceptibility stemming from a failure to remove DNA crosslinks and other chromosomal lesions. Within the FA DNA damage response pa...
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Article
Open AccessThe Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
The transition of hematopoiesis from the fetal liver (FL) to the bone marrow (BM) is incompletely characterized. We demonstrate that the Wiskott–Aldrich syndrome verprolin-homologous protein (WAVE) complex 2 i...
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Article
Open AccessSynthetic lethality in malignant pleural mesothelioma with PARP1 inhibition
Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have so...
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Article
Open AccessThe DNA repair component Metnase regulates Chk1 stability
Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. Metnase (also termed SETMAR) is a SET histone methylase and transposase nuclease protein that p...
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Chapter
Mountain Gorillas: A Shifting Demographic Landscape
Large-scale habitat destruction and poaching in the 1950s, 1960s, and 1970s had major impacts on the population size and demography of mountain gorillas (Gorilla beringei beringei) in Rwanda. In those three decad...
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Article
Cytotoxic activity of the titanium alkoxide (OPy)2Ti(4AP)2 against cancer colony forming cells
A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines using colon...
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Article
Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer
A pharmacological-based global screen for epigenetically silenced tumor suppressor genes was performed in MCF-7 and MDA-MB-231 breast cancer cells. Eighty-one genes in MCF-7 cells and 131 in MDA-MB-231 cells w...
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Article
BRCA1 transactivates the cyclin-dependent kinase inhibitor p27Kip1
The p27Kip1 is a member of the universal cyclin-dependent kinase inhibitor family. Previously, immunochemical analysis of a series of breast cancer cell lines demonstrated a correlation between the expression of ...
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Article
Survey of Grauer's Gorillas (Gorilla gorilla graueri) and Eastern Chimpanzees (Pan troglodytes schweinfurthi) in the Kahuzi-Biega National Park Lowland Sector and Adjacent Forest in Eastern Democratic Republic of Congo
We describe the distribution and estimate densities of Grauer's gorillas (Gorilla gorilla graueri) and eastern chimpanzees (Pan troglodytes schweinfurthi) in a 12,770-km 2 area of lowland forest between the Lowa...
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Article
Gorilla diet in the Lopé Reserve, Gabon:
The results of an analysis of gorilla diet in the Lopé Reserve, Gabon are presented. Samples were assayed for nutrients and plant secondary compounds (total phenols, condensed tannins and alkaloids) in an atte...
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Article
Chimpanzees of Sapo Forest, Liberia: Density, nests, tools and meat-eating
Two months were spent surveying for chimpanzees (Pan troglodytes verus) in the Sapo Forest, eastern Liberia. The population density, as estimated from the number of nests found on transects, appears lower than th...