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  1. No Access

    Protocol

    In Vitro Reconstitutive Base Excision Repair (BER) Assay

    The mammalian cell genome is continuously exposed to endogenous and exogenous insults that modify its DNA. These modifications can be single-base lesions, bulky DNA adducts, base dimers, base alkylation, cytos...

    Aruna S. Jaiswal, Elizabeth A. Williamson… in Base Excision Repair Pathway (2023)

  2. Article

    Open Access

    Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition

    Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have so...

    Gayathri Srinivasan, Gurjit Singh Sidhu… in Cancer Chemotherapy and Pharmacology (2017)

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  3. No Access

    Chapter

    Exposure to Environmental Mutagens: APC and Colorectal Carcinogenesis

    Environmental mutagens are global health hazards and a major risk factor for colon cancer development. Environmental mutagens include a variety of genotoxic carcinogenic compounds including polycyclic aromatic...

    Aruna S. Jaiswal, Melissa L. Armas… in Environmental Factors, Genes, and the Deve… (2010)

  4. No Access

    Article

    Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells

    Mutations of the adenomatous polyposis coli (APC) and p53 genes are commonly found in colorectal cancers. We therefore analyzed the relative roles of APC and p53 in the induction of apoptosis of colon cancer ...

    Aruna S. Jaiswal, Satya Narayan in Journal of Cancer Research and Clinical Oncology (2004)

  5. No Access

    Article

    Cigarette smoke condensate-induced transformation of normal human breast epithelial cells in vitro

    In the present study, we showed that a single-dose treatment of normal breast epithelial cell line, MCF10A, for 72 h with cigarette smoke condensate (CSC) resulted in a transformed phenotype. The anchorage-dep...

    Satya Narayan, Aruna S Jaiswal, Diana Kang, Pratima Srivastava, Gokul M Das… in Oncogene (2004)

  6. Article

    Open Access

    N-Methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA

    Cellular senescence is a state in which mammalian cells enter into an irreversible growth arrest and altered biological functions. The senescence response in mammalian cells can be elicited by DNA-damaging age...

    Aruna S Jaiswal, Asha S Multani, Sen Pathak, Satya Narayan in Molecular Cancer (2004)

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  7. No Access

    Article

    β-Catenin-mediated transactivation and cell–cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells

    The development of nontoxic natural agents with chemopreventive activity against colon cancer is the focus of investigation in many laboratories. Curcumin (feruylmethane), a natural plant product, possesses su...

    Aruna S Jaiswal, Benjamin P Marlow, Nirupama Gupta, Satya Narayan in Oncogene (2002)

  8. No Access

    Article

    Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1/Cip-1

    Molecular interactions among cell cycle and DNA repair proteins have been described, but the impact of many of these interactions on cell cycle control and DNA repair remains unclear. The cyclin-dependent kina...

    Aruna S Jaiswal, Linda B Bloom, Satya Narayan in Oncogene (2002)