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  1. No Access

    Article

    Chimpanzees of Sapo Forest, Liberia: Density, nests, tools and meat-eating

    Two months were spent surveying for chimpanzees (Pan troglodytes verus) in the Sapo Forest, eastern Liberia. The population density, as estimated from the number of nests found on transects, appears lower than th...

    James R. Anderson, Elizabeth A. Williamson, Janis Carter in Primates (1983)

  2. No Access

    Article

    Gorilla diet in the Lopé Reserve, Gabon:

    The results of an analysis of gorilla diet in the Lopé Reserve, Gabon are presented. Samples were assayed for nutrients and plant secondary compounds (total phenols, condensed tannins and alkaloids) in an atte...

    M. Elizabeth Rogers, Fiona Maisels, Elizabeth A. Williamson, Michel Fernandez… in Oecologia (1990)

  3. No Access

    Article

    Survey of Grauer's Gorillas (Gorilla gorilla graueri) and Eastern Chimpanzees (Pan troglodytes schweinfurthi) in the Kahuzi-Biega National Park Lowland Sector and Adjacent Forest in Eastern Democratic Republic of Congo

    We describe the distribution and estimate densities of Grauer's gorillas (Gorilla gorilla graueri) and eastern chimpanzees (Pan troglodytes schweinfurthi) in a 12,770-km 2 area of lowland forest between the Lowa...

    Jefferson S. Hall, Lee J. T. White… in International Journal of Primatology (1998)

  4. No Access

    Article

    BRCA1 transactivates the cyclin-dependent kinase inhibitor p27Kip1

    The p27Kip1 is a member of the universal cyclin-dependent kinase inhibitor family. Previously, immunochemical analysis of a series of breast cancer cell lines demonstrated a correlation between the expression of ...

    Elizabeth A Williamson, Farnaz Dadmanesh, H Phillip Koeffler in Oncogene (2002)

  5. No Access

    Article

    Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer

    A pharmacological-based global screen for epigenetically silenced tumor suppressor genes was performed in MCF-7 and MDA-MB-231 breast cancer cells. Eighty-one genes in MCF-7 cells and 131 in MDA-MB-231 cells w...

    Ido Wolf, Shikha Bose, Julian C. Desmond… in Breast Cancer Research and Treatment (2007)

  6. No Access

    Article

    Cytotoxic activity of the titanium alkoxide (OPy)2Ti(4AP)2 against cancer colony forming cells

    A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines using colon...

    Elizabeth A. Williamson, Timothy J. Boyle, Rebecca Raymond… in Investigational New Drugs (2012)

  7. No Access

    Chapter

    Mountain Gorillas: A Shifting Demographic Landscape

    Large-scale habitat destruction and poaching in the 1950s, 1960s, and 1970s had major impacts on the population size and demography of mountain gorillas (Gorilla beringei beringei) in Rwanda. In those three decad...

    Elizabeth A. Williamson in Primates and Cetaceans (2014)

  8. Article

    Open Access

    The DNA repair component Metnase regulates Chk1 stability

    Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. Metnase (also termed SETMAR) is a SET histone methylase and transposase nuclease protein that p...

    Elizabeth A Williamson, Yuehan Wu, Sudha Singh, Michael Byrne, Justin Wray… in Cell Division (2014)

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  9. Article

    Open Access

    Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition

    Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have so...

    Gayathri Srinivasan, Gurjit Singh Sidhu… in Cancer Chemotherapy and Pharmacology (2017)

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  10. Article

    Open Access

    The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

    The transition of hematopoiesis from the fetal liver (FL) to the bone marrow (BM) is incompletely characterized. We demonstrate that the Wiskott–Aldrich syndrome verprolin-homologous protein (WAVE) complex 2 i...

    Lijian Shao, Jianhui Chang, Wei Feng, **aoyan Wang… in Nature Communications (2018)

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  11. Article

    Open Access

    DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

    Fanconi anemia (FA) is a multigenic disease of bone marrow failure and cancer susceptibility stemming from a failure to remove DNA crosslinks and other chromosomal lesions. Within the FA DNA damage response pa...

    Fengshan Liang, Adam S. Miller, Simonne Longerich, Caroline Tang… in Nature Communications (2019)

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  12. No Access

    Article

    Tapanuli orangutan endangered by Sumatran hydropower scheme

    William F. Laurance, Serge A. Wich, Onrizal Onrizal… in Nature Ecology & Evolution (2020)

  13. No Access

    Article

    Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis

    The BCL-2 family of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1, can mediate survival of some types of cancer. DT2216 is a PROteolysis-TArgeting Chimera (PROTAC) that degrades BCL-XL specifically and is i...

    Arunima Jaiswal, Aruna Jaiswal… in Cancer Chemotherapy and Pharmacology (2023)

  14. No Access

    Protocol

    In Vitro Reconstitutive Base Excision Repair (BER) Assay

    The mammalian cell genome is continuously exposed to endogenous and exogenous insults that modify its DNA. These modifications can be single-base lesions, bulky DNA adducts, base dimers, base alkylation, cytos...

    Aruna S. Jaiswal, Elizabeth A. Williamson… in Base Excision Repair Pathway (2023)