23 Result(s)
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Chapter
Heterogeneity of Melanoma with Stem Cell Properties
Metastatic melanoma continues to present a significant challenge—with a cure rate of less than 10% and a median survival of 6–9 months. Despite noteworthy advances in the field, the heterogeneity of melanoma t...
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Article
Plasticity underlies tumor progression: role of Nodal signaling
The transforming growth factor beta (TGFβ) superfamily member Nodal is an established regulator of early embryonic development, with primary roles in endoderm induction, left-right asymmetry, and primitive str...
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Article
Maspin: molecular mechanisms and therapeutic implications
Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been characterized as a tumor suppressor gene in multiple cancer types. Among the established anti-tumor effects of Maspin are ...
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Article
Open AccessPotential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer
The re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of Nodal ...
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Chapter
Lessons from Embryogenesis
The plastic phenotype of aggressive melanoma has presented a significant challenge in the detection and targeting of tumor cells exhibiting stem cell-like characteristics. As the molecular signaling pathways u...
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Article
Open AccessMicroenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors
Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. An animal model of...
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Chapter
Plasticity Underlying Multipotent Tumor Stem Cells
Aggressive cancer cells manifest stem-cell-like qualities that allow them to self-renew and to derive a heterogeneous tumor. Ultimately, this multipotent phenotype facilitates metastasis and resistance to ther...
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Article
Open AccessThe Epigenetic Influence of Tumor and Embryonic Microenvironments: How Different are They?
The microenvironment is being increasingly recognized as a critical component in tumor progression and metastases. As such, the bi-directional signaling of extracellular mediators that promote tumor growth wit...
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Article
Reprogramming metastatic tumour cells with embryonic microenvironments
Aggressive tumour cells, such as melanoma, share many characteristics with embryonic progenitors, which contribute to the conundrum of tumour cell plasticity. ...
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Chapter
Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity
Tumor cell plasticity poses a significant clinical challenge in that the fate and function of tumor cells can be elusive until a tumor mass is evident. An overview of key molecular events in prostate cancer, i...
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Chapter
Vasculogenic Mimicry: Angiogenesis in Disguise?
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Article
Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma
The molecular 'signature' of aggressive melanoma cells is illustrative of an undifferentiated cell with a gene-expression profile that is similar to that of em...
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Article
Molecular determinants of human uveal melanoma invasion and metastasis
The molecular analysis of cancer has benefited tremendously from the sequencing of the human genome integrated with the science of bioinformatics. Microarray analysis technology has the potential to classify t...
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Article
Molecular biology of breast cancer metastasis Molecular expression of vascular markers by aggressive breast cancer cells
During embryogenesis, the formation of primary vascular networks occurs via the processes of vasculogenesis and angiogenesis. In uveal melanoma, vasculogenic mimicry describes the 'embryonic-like' ability of a...
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Article
An altered gene expression profile is associated with tumour vasculogenesis by human melanoma cells
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Article
Molecular Role(s) for Integrins in Human Melanoma Invasion
There are fundamental issues regarding the role of integrins in human disease which remain to be elucidated. Human cutaneous melanoma is an attractive model for studying integrin involvement in tumor progressi...
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Article
Role for glucose transporter 1 protein in human breast cancer
Glycolysis is increased in cancer cells compared with normal cells. It has been shown that glucose enters cells via a family of five functional glucose transporters (GLUT). However, GLUT expression appears to ...
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Article
Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis
Recent work has shown that chemically modified tetracyclines (CMTs) are potent inhibitors of matrix metal-loproteinase (MMP) activity, both in vitro and in vivo, which is distinct from their antimicrobial activit...
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Article
Heterogeneous expression of invasive and metastatic properties in a prostate tumor model
Cellular heterogeneity of neoplasia is well demonstrated in the Dunning R-3327 rat prostate adenocarcinoma. In this study, we measured the differential expression of invasive and metastatic properties of this ...
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Article
Role of intermediate filaments in migration, invasion and metastasis
The expression of intermediate filament proteins is remarkably tissue-specific which suggests that the intermediate filament (IF) type(s) present in cells is somehow related to their biological function. Howev...
