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Article
A normative chart for cognitive development in a genetically selected population
Certain pathogenic genetic variants impact neurodevelopment and cause deviations from typical cognitive trajectories. Understanding variant-specific cognitive trajectories is clinically important for informed ...
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Article
Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome
The 22q11.2 deletion syndrome (22q11DS) is associated with a 20–25% risk of schizophrenia. In a cohort of 962 individuals with 22q11DS, we examined the shared genetic basis between schizophrenia and schizophre...
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Article
The Dutch Bipolar Offspring Study: Cognitive Development and Psychopathology
Various aspects of the relationship between cognitive impairment and bipolar disorder are not clear yet. This study examines cognitive and educational functioning prospectively in offspring at familial risk fo...
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Article
Open AccessEarly interventions in risk groups for schizophrenia: what are we waiting for?
Intervention strategies in adolescents at ultra high-risk (UHR) for psychosis are promising for reducing conversion to overt illness, but have only limited impact on functional outcome. Recent studies suggest ...