-
Article
Whole blood thiamine, intravenous thiamine supplementation and delirium occurrence in the intensive care unit: retrospective cohort analyses
Thiamine di-phosphate is an essential cofactor in glucose metabolism, glutamate transformation and acetylcholinesterase activity, pathways associated with delirium occurrence. We hypothesised that a deficiency...
-
Article
Open AccessClustering of antipsychotic-naïve patients with schizophrenia based on functional connectivity from resting-state electroencephalography
Schizophrenia is associated with aberrations in the Default Mode Network (DMN), but the clinical implications remain unclear. We applied data-driven, unsupervised machine learning based on resting-state electr...
-
Article
Open AccessMental, cognitive and physical outcomes after intensive care unit treatment during the COVID-19 pandemic: a comparison between COVID-19 and non-COVID-19 patients
To compare mental, cognitive and physical outcomes between COVID-19 and non-COVID-19 patients, 3–6 months after Intensive Care Unit (ICU) treatment during the COVID-19 pandemic and to compare mental outcomes b...
-
Article
Open AccessMuva physical activity intervention to improve social functioning in people with a severe mental illness: study protocol of a pragmatic stepped wedge cluster randomized trial
People with severe mental illness (SMI) often suffer from long-lasting symptoms that negatively influence their social functioning, their ability to live a meaningful life, and participation in society. Interv...
-
Article
Open AccessAuthor Correction: Functional connectome differences in individuals with hallucinations across the psychosis continuum
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessFunctional connectome differences in individuals with hallucinations across the psychosis continuum
Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis con...
-
Article
Open AccessFunctional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis
Psychotic experiences have been proposed to lie on a spectrum, ranging from subclinical experiences to treatment-resistant schizophrenia. We aimed to characterize functional connectivity and brain network char...
-
Article
Open AccessOscillatory brain activity associates with neuroligin-3 expression and predicts progression free survival in patients with diffuse glioma
Diffuse gliomas have local and global effects on neurophysiological brain functioning, which are often seen as ‘passive’ consequences of the tumor. However, seminal preclinical work has shown a prominent role ...
-
Article
Open AccessDynamic hub load predicts cognitive decline after resective neurosurgery
Resective neurosurgery carries the risk of postoperative cognitive deterioration. The concept of ‘hub (over)load’, caused by (over)use of the most important brain regions, has been theoretically postulated in ...
-
Article
Open AccessEarly interventions in risk groups for schizophrenia: what are we waiting for?
Intervention strategies in adolescents at ultra high-risk (UHR) for psychosis are promising for reducing conversion to overt illness, but have only limited impact on functional outcome. Recent studies suggest ...
-
Article
Open AccessLearning of anticipatory responses in single neurons of the human medial temporal lobe
Neuronal processes underlying the formation of new associations in the human brain are not yet well understood. Here human participants, implanted with depth electrodes in the brain, learned arbitrary associat...
-
Chapter
Neural network analysis and its application in neurosurgical planning
The human brain is the most complex object known to man. Unraveling its wiring and functioning is one of the greatest challenges in modern science. It is now widely acknowledged that the brain should be seen a...
-
Article
Open AccessEpilepsy is related to theta band brain connectivity and network topology in brain tumor patients
Both epilepsy patients and brain tumor patients show altered functional connectivity and less optimal brain network topology when compared to healthy controls, particularly in the theta band. Furthermore, the ...
