8 Result(s)
within
Ekkehard Grünig
Rheumatology
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Article
Open AccessExercise training in pulmonary arterial hypertension associated with connective tissue diseases
The objective of this prospective study was to assess short- and long-term efficacy of exercise training (ET) as add-on to medical therapy in patients with connective tissue disease-associated pulmonary arteri...
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Article
Open AccessBorderline pulmonary arterial pressure in systemic sclerosis patients: a post-hoc analysis of the DETECT study
Patients with mean pulmonary artery pressures (mPAP) of 21 to 24 mm Hg have a so-called borderline elevation of mPAP (BoPAP)—a condition thought to represent early-stage pulmonary arterial vasculopathy. Based ...
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Article
Open AccessStress Doppler echocardiography for early detection of systemic sclerosis-associated pulmonary arterial hypertension
In patients with systemic sclerosis (SSc), associated pulmonary arterial hypertension (SSc-APAH) is the leading cause of death. The objective of this prospective screening study was to analyse sensitivity and ...
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Article
Right atrial morphology and function in patients with systemic sclerosis compared to healthy controls: a two-dimensional strain study
Enlargement and dysfunction of the right atrium might be an early sign for pulmonary hypertension in systemic sclerosis (SSc). This is the first study to analyse right atrial morphology and function in SSc pat...
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Article
Open AccessEarly treatment with ambrisentan of mildly elevated mean pulmonary arterial pressure associated with systemic sclerosis: a randomized, controlled, double-blind, parallel group study (EDITA study)
The objective of this randomized, placebo-controlled, double-blind, parallel group, trial was to assess the effect of ambrisentan on mean pulmonary arterial pressure (mPAP) in patients with systemic sclerosis ...
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Article
Open AccessPrognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis
The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulm...
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Article
Open AccessHypochromic red cells as a prognostic indicator of survival among patients with systemic sclerosis screened for pulmonary hypertension
Patients with systemic sclerosis (SSc) are frequently affected by iron deficiency, particularly those with pulmonary hypertension (PH). The first data indicate the prognostic importance of hypochromic red cell...
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Article
Open AccessOral Treprostinil is Associated with Improved Survival in FREEDOM-EV and its Open-Label Extension
In the event-driven FREEDOM-EV trial, oral treprostinil delayed clinical worsening in patients with pulmonary arterial hypertension (PAH). Open-label extension studies offer additional data about tolerability,...
