98 Result(s)

Article

COVID-19 severity, breakthrough infections and vaccine safety in young individuals with autoimmune diseases: insights from the COVAD study

Notwithstanding the wealth of literature on COVID-19, studies focusing on young adults with autoimmune diseases (AD) are lacking. To determine early (within 7 days) and late (after 7 days) anti-SARS-CoV-2 vacc...

Alessia Alunno, Francesco Carubbi, Ai Lyn Tan, Parikshit Sen… in Rheumatology International (2024)

Article

Evaluating the effects of digital stromal vascular fraction injections in systemic sclerosis patients: a retrospective study

Managing hand symptoms in patients with systemic sclerosis is difficult, and the current treatments often provide only limited relief of. In 2014 a new treatment for theses patients was proposed for improving ...

Viviane Nietlispach, Inga S. Besmens, Suzana Jordan… in European Journal of Plastic Surgery (2024)

Article

Impacts of priming on distinct immunosuppressive mechanisms of mesenchymal stromal cells under translationally relevant conditions

The multimodal properties of mesenchymal stromal cells (MSCs), particularly their ability to modulate immune responses is of high interest in translational research. Pro-inflammatory, hypoxic, and 3D culture p...

Nick Herger, Irina Heggli, Tamara Mengis, Jan Devan… in Stem Cell Research & Therapy (2024)

Article

The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis

Although patients with rheumatoid arthritis (RA) typically exhibit symmetrical joint involvement, some patients develop alternative disease patterns in response to treatment, suggesting that different molecula...

Muriel Elhai, Raphael Micheroli, Miranda Houtman… in Nature Communications (2023)

Article

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels

The activation of stress response pathways in synovial fibroblasts (SF) is a hallmark of rheumatoid arthritis (RA). CBP and p300 are two highly homologous histone acetyl transferases and writers of activating ...

Monika Krošel, Marcel Gabathuler, Larissa Moser… in Scientific Reports (2023)

Article

Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start

Rheumatoid arthritis (RA) has a variable impact on different synovial joints, with inflammation being more commonly observed in some joints than others. Emerging evidence suggests that the anatomical variation...

Adrian Ciurea, Oliver Distler, Kenneth Kwok, Hye** Jo… in Arthritis Research & Therapy (2023)

Article

Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study

Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute to vaccine hesitancy. We studied delayed-onset vaccine adverse events (A...

Bohdana Doskaliuk, Naveen Ravichandran, Parikshit Sen… in Rheumatology International (2023)

Article

Anaemia is associated with higher disease activity in axial spondyloarthritis but is not an independent predictor of spinal radiographic progression: data from the Swiss Clinical Quality Management Registry

As anaemia represents a biomarker for increased radiographic damage in rheumatoid arthritis, we aimed to investigate whether it independently predicts spinal radiographic progression in axial spondyloarthritis...

Raphael Micheroli, Seraphina Kissling, Kristina Bürki… in Clinical Rheumatology (2023)

Article

High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey

Idiopathic inflammatory myopathies (IIMs) confer a significant risk of disability and poor quality of life, though fatigue, an important contributing factor, remains under-reported in these individuals. We aim...

Silvia Grignaschi, Minchul Kim, Giovanni Zanframundo… in Rheumatology International (2023)

Article

Systemic sclerosis and COVID-19 vaccine safety: short-term insights from the global COVID-19 vaccination in autoimmune disease (COVAD) survey

The safety profile of COVID-19 vaccines is understudied in patients with systemic sclerosis (SSc). We compared short-term adverse events (AEs) 7 days following vaccination in patients with SSc vs other rheumat...

R. Naveen, Darpan R. Thakare, Masataka Kuwana… in Rheumatology International (2023)

Article

A Multi-component Intervention (NEXpro) Reduces Neck Pain-Related Work Productivity Loss: A Randomized Controlled Trial Among Swiss Office Workers

Purpose Neck pain is common among office workers and leads to work productivity loss. This study aimed to investigate the effect of a multi-component intervention on neck pain-related work productivity loss amon...

Andrea Martina Aegerter, Manja Deforth… in Journal of Occupational Rehabilitation (2023)

Article

Characteristics of ScleroID highlighting musculoskeletal and internal organ implications in patients afflicted with systemic sclerosis

Systemic sclerosis (SSc) is a multi-organ disease with impaired health-related quality of life (HRQoL). The EULAR SSc Impact of Disease (ScleroID) is a newly introduced SSc-specific patient-reported outcome to...

Gabriella Nagy, Rucsandra Dobrota, Mike Oliver Becker… in Arthritis Research & Therapy (2023)

Article

HLA-B27 as a predictor of effectiveness of treatment with TNF inhibitors in axial spondyloarthritis: data from the Swiss Clinical Quality Management Registry

To explore the impact of the human leucocyte antigen (HLA)-B27 on the effectiveness of tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA).

Fabienne Fröhlich, Raphael Micheroli, Monika Hebeisen… in Clinical Rheumatology (2023)

Article

Site-specific assessment of spinal radiographic progression improves detection of TNF blocker-associated disease modification in axial spondyloarthritis: longitudinal observational data from the Swiss Clinical Quality Management Registry

To analyse whether time-varying treatment with tumour necrosis factor inhibitors (TNFi) in radiographic axial spondyloarthritis (r-axSpA) has a differential impact on structural damage progression on different...

Vjara Popova, Seraphina Kissling, Raphael Micheroli… in Arthritis Research & Therapy (2023)

Article

Hypochromic red cells as a prognostic indicator of survival among patients with systemic sclerosis screened for pulmonary hypertension

Patients with systemic sclerosis (SSc) are frequently affected by iron deficiency, particularly those with pulmonary hypertension (PH). The first data indicate the prognostic importance of hypochromic red cell...

Panagiota Xanthouli, Ojan Gordjani, Nicola Benjamin… in Arthritis Research & Therapy (2023)

Article

Author Correction: The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions

Mara Stellato, Matthias Dewenter, Michal Rudnik, Amela Hukara… in Communications Biology (2023)

Article

The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions

Fibrotic changes in the myocardium and cardiac arrhythmias represent fatal complications in systemic sclerosis (SSc), however the underlying mechanisms remain elusive. Mice overexpressing transcription factor ...

Mara Stellato, Matthias Dewenter, Michal Rudnik, Amela Hukara… in Communications Biology (2023)