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  1. No Access

    Article

    Angiotensin-converting enzyme as a GPIase: a critical reevaluation

    Lilia Leisle, Edward T Parkin, Anthony J Turner, Nigel M. Hooper in Nature Medicine (2005)

  2. Article

    Open Access

    Herpes simplex virus interferes with amyloid precursor protein processing

    The early events underlying Alzheimer's disease (AD) remain uncertain, although environmental factors may be involved. Work in this laboratory has shown that the combination of herpes simplex virus type 1 (HSV...

    Suzanne J Shipley, Edward T Parkin, Ruth F Itzhaki, Curtis B Dobson in BMC Microbiology (2005)

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    Chapter

    The Role of Proteolysis in Alzheimer’s Disease

    Alzheimer’s disease is characterised by the progressive deposition of the 4 kDa β-amyloid peptide (Aβ) in extracellular senile plaques in the brain, Aβ is derived by proteolytic cleavage of the amyloid precurs...

    Nigel M. Hooper, Alison J. Trew… in Cellular Peptidases in Immune Functions an… (2002)

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    Protocol

    Distribution of Presenilins and Amyloid Precursor Protein (APP) in Detergent-Insoluble Membrane Domains

    Until recently, the detergent insolubility of certain membrane-associated proteins was singularly attributed to an association with the cytoskeleton. However, in 1988 we observed that a number of glycosyl-phos...

    Edward T. Parkin, Anthony J. Turner, Nigel M. Hooper in Alzheimer's Disease (2000)

  5. No Access

    Protocol

    Glycosylation and Glycosylphosphatidylinositol Membrane Anchors

    Glycosylation is one of the most common covalent modifications of proteins. It is not normally a reversible phenomenon and does not play a role in regulation of protein activity. Both glycoproteins and glycoli...

    Anthony J. Turner, Edward T. Parkin, Nigel M. Hooper in Regulatory Protein Modification (1997)