4 Result(s)
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Eduardo M. Rego
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessInhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability
Metabolic programs can differ substantially across genetically distinct subtypes of acute myeloid leukemia (AML). These programs are not static entities but can change swiftly as a consequence of extracellular...
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Article
Open AccessThe Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia
Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable dete...
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Article
Open AccessMolecular-Based Score inspired on metabolic signature improves prognostic stratification for myelodysplastic syndrome
Deregulated cellular energetics is formally incorporated as an emerging hallmark of cancer, however little is known about its processes in myelodysplastic syndromes (MDS). Using transcriptomic data of CD34+ ce...
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Article
Open AccessNTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia
Non-T cell activation linker (NTAL) is a lipid raft-membrane protein expressed by normal and leukemic cells and involved in cell signaling. In acute promyelocytic leukemia (APL), NTAL depletion from lipid raft...
