22 Result(s)

Article

Prognostic implications of ΔNp73/TAp73 expression ratio in core-binding factor acute myeloid leukemia

Maria L. Salustiano-Bandeira, Amanda Moreira-Aguiar… in Blood Cancer Journal (2024)

Article

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability

Metabolic programs can differ substantially across genetically distinct subtypes of acute myeloid leukemia (AML). These programs are not static entities but can change swiftly as a consequence of extracellular...

Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins… in Nature Communications (2022)

Article

The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable dete...

Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins… in Nature Communications (2022)

Article

MLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model

Although the mixed lineage leukemia 5 (MLL5) gene has prognostic implications in acute promyelocyte leukemia (APL), the underlying mechanism remains to be elucidated. Here, we demonstrate the critical role exerte...

Diego A. Pereira-Martins, Isabel Weinhäuser, Juan Luiz Coelho-Silva… in Cell Death & Disease (2021)

Article

Molecular-Based Score inspired on metabolic signature improves prognostic stratification for myelodysplastic syndrome

Deregulated cellular energetics is formally incorporated as an emerging hallmark of cancer, however little is known about its processes in myelodysplastic syndromes (MDS). Using transcriptomic data of CD34+ ce...

Juan L. Coelho-Silva, Douglas R. A. Silveira… in Scientific Reports (2021)

Article

NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia

Non-T cell activation linker (NTAL) is a lipid raft-membrane protein expressed by normal and leukemic cells and involved in cell signaling. In acute promyelocytic leukemia (APL), NTAL depletion from lipid raft...

Carolina Hassibe Thomé, Germano Aguiar Ferreira… in Scientific Reports (2020)

Article

Targeting the mitochondria in acute myeloid leukemia

Acute myeloid leukemia (AML) is a clonal hematologic neoplasm characterized by heterogeneity of genetic abnormalities found at diagnosis. These abnormalities serve to classify patients by risk group into low, ...

Silvia Elena Sánchez-Mendoza, Eduardo M. Rego in Applied Cancer Research (2017)

Article

Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model

Halofuginone (HF) is a low-molecular-weight alkaloid that has been demonstrated to interfere with Metalloproteinase-2 (MMP-2) and Tumor Growth Factor-β (TGF-β) function and, to present antiangiogenic, antiprol...

Patricia A. Assis… in Journal of Experimental & Clinical Cancer … (2015)

Article

Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia

CD56 expression has been associated with a poor prognosis in lymphoid neoplasms, including T-cell acute lymphoblastic leukemia (T-ALL). MicroRNAs (miRNAs) play an important role in lymphoid differentiation, an...

Hamilton L Gimenes-Teixeira, Antonio R Lucena-Araujo… in Experimental Hematology & Oncology (2013)

Article

Erratum to: Results of FLT3 mutation screening and correlations with immunophenoty** in 169 Brazilian patients with acute myeloid leukemia

Antonio R. Lucena-Araujo, Danielle L. Souza… in Annals of Hematology (2010)