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Article
Acquired skewing of Lyonization remains stable for a prolonged period in healthy blood donors
The pattern of X-chromosome inactivation (XCIP), or Lyonization, can be used to distinguish monoclonal from polyclonal cell populations in females. However, a skewed XCIP exists in hematopoietic cells in appro...
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Article
Degradable dU-based DNA template as a standard in real-time PCR quantitation
Development of real-time quantitative PCR assays requires suitable positive controls. For assays with clinical applications, these controls may be difficult to obtain because some molecular aberrations are rar...
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Article
Freezing of PCR master mixture retains full amplification activity and facilitates PCR standardization for molecular diagnostics and real-time PCR
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Article
Specific detection of myeloma plasma cells using anti-idiotypic single chain antibody fragments selected from a phage display library
Bone marrow plasma cells constitute the bulk of malignant cells in multiple myeloma patients. B-lymphocytes having immunoglobulin heavy chain gene rearrangements identical to those of the malignant clone (clon...