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    Article

    Acquired skewing of Lyonization remains stable for a prolonged period in healthy blood donors

    The pattern of X-chromosome inactivation (XCIP), or Lyonization, can be used to distinguish monoclonal from polyclonal cell populations in females. However, a skewed XCIP exists in hematopoietic cells in appro...

    JP van Dijk, L Heuver, E Stevens-Linders, JH Jansen, EJBM Mensink in Leukemia (2002)

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    Degradable dU-based DNA template as a standard in real-time PCR quantitation

    Development of real-time quantitative PCR assays requires suitable positive controls. For assays with clinical applications, these controls may be difficult to obtain because some molecular aberrations are rar...

    JLA Pennings, LTF Van de Locht, JH Jansen, BA Van der Reijden, T De Witte in Leukemia (2001)

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    Freezing of PCR master mixture retains full amplification activity and facilitates PCR standardization for molecular diagnostics and real-time PCR

    TFCM Smetsers, EHP Stevens, LTF van de Locht, EJBM Mensink in Leukemia (1998)

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    Article

    Specific detection of myeloma plasma cells using anti-idiotypic single chain antibody fragments selected from a phage display library

    Bone marrow plasma cells constitute the bulk of malignant cells in multiple myeloma patients. B-lymphocytes having immunoglobulin heavy chain gene rearrangements identical to those of the malignant clone (clon...

    PMW Willems, RMA Hoet, ELPG Huys, JMH Raats, EJBM Mensink, RAP Raymakers in Leukemia (1998)