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Chapter
Dopaminforschung heute und morgen — L-Dopa in der Zukunft
Dopamin (DA) wurde von Carlsson et al. [1] entdeckt. Der wesentliche und für die nachfolgenden Entdeckungen essentielle Versuch, Mäuse und Kaninchen durch Einwirkung von Reserpin in ihrer Bewegung zu sedieren und...
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Article
Reduced concentrations and increased metabolism of biogenic amines in a single case of Rett-syndrome: apostmortem brain study
Preliminary data of a postmortem brain study in a single case with Rett-syndrome compared to a single control case show a severe reduction of dopamine (DA), noradrenaline (NA), and serotonin (5-HT) in most reg...
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Chapter
Monoaminerge Läsion bei seniler Demenz vom Alzheimer-Typ (SDAT): Vorläufige Befunde
Acetylcholin (ACH) und die Monoamine Dopamin (DA), Noradrenalin (NA) und Serotonin (5-Hydroxytryptamin; 5-HT) gelten als zentrale Neurotransmitter mit Synthese vorwiegend in Arealen des Hirnstammes. Zellkörper...
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Article
Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 255% of iron...
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Book and Conference Proceedings
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Chapter and Conference Paper
Pathobiochemistry of the extrapyramidal system: a “short note” review
Evidence is presented to show that in Parkinson’s disease (PD) there exists a topographical degeneration in the nigrostriatal dopamine system. This finding may account for response variabilities and side effec...
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Chapter and Conference Paper
The Role of Dopamine in the Control of Neurobiological Functions
It is only 30 years since dopamine (DA) was first measured in human brain tissue by Sano [98] (Fig.1). One year later Ehringer and Hornykiewicz [34] demonstrated a striatal DA deficiency in Parkinson’s disease...
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Article
Biogenic amines and their metabolites in neurodegenerative diseases
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Article
The reflection of multiple biochemical deficits in nucleus basalis of Meynert of Alzheimer brains to differential scanning thermograms
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Article
Brain quinolinic acid in Alzheimer's dementia
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Article
Brain quinolinic acid in Alzheimer's dementia
Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and c...
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Article
Plasma moclobemide and metabolites: lack of correlation with clinical response and biogenic amines
The concentration of the reversible monoamine oxidase type-A (MAO-A) inhibitor moclobemide (Ro 11-1163) was determined by high pressure liquid chromatography (HPLC) in the plasma of 16 depressives treated with...
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Chapter and Conference Paper
Brofaromine (CGP 11 305 A): estimation of plasma concentrations by a biologic technique as compared to liquid chromatography
In an open clinical trial 13 depressives significantly improved under the reversible and selective type-A monoamine oxidase (MAO) inhibitor brofaromine. The inhibitory potency of deproteinated plasma on a crud...
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Chapter and Conference Paper
Clinical, biochemical and psychometric findings with the new MAO-A-inhibitors moclobemide and brofaromine in patients with major depressive disorder
N = 53 inpatients with major depressive disorder have been treated with the reversible, selective MAO-A-inhibitors moclobemide (double-blind versus maprotiline) and brofaromine (open study), respectively. Clin...
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Chapter and Conference Paper
Reflection of changes in membrane constituents in various regions of Alzheimer brains to differential scanning thermograms
To test whether changes in basic biochemical membrane constituents were reflected in membrane fluidity measurements, protein, total lipids, triglycerides, lecithine, cholesterol and alkaline phosphatase were d...
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Chapter
Senile dementia of Alzheimer’s type and Parkinson’s disease: neurochemical overlaps and specific differences
Parkinson’s disease (PD) is characterized by a clear rank order with respect to neuropathological findings. Both substantia nigra (SN) and locus coeruleus (LC) are severely damaged, whilst nucleus raphe dorsal...
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Chapter and Conference Paper
Urinary dopamine sulfate: regulations and significance in neurological disorders
Dopamine-3-O-sulfate (DA-3-O-S) and dopamine-4-O-sulfate (DA-4-O-S) are important end products of L-dopa metabolism. Therefore they may give indications of disturbances in the peripheral metabolism of catechol...
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Article
Biogenic amines and metabolites in spinal cord of patients with Parkinson's disease and amyotrophic lateral sclerosis
In four human controls, four cases of Parkinson's disease and three cases of amyotrophic lateral sclerosis analysis of dopamine, noradrenaline, serotonin and the metabolites 3,4-dihydroxyphenylacetic acid, hom...
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Chapter and Conference Paper
Butyryl-Cholinesterase, biogene Amine und akustisch evozierte P300 nach cholinerger Modulation bei Probanden
Die Abhängigkeit kognitiver Funktionen von der Aktivität des zentralen cholinergen Neurotransmittersystems ist seit langem bekannt (Drachman 1977). Bei gesunden Probanden führt die Hemmung der cholinergen Neur...
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Chapter and Conference Paper
Das psychotrope Wirkprofil neuentwickelter substituierter Benzamide
Substituierte Benzamide werden bislang aufgrund ihres speziellen pharmakologischen Wirkprofils als eigenständige Gruppe psychotroper Substanzen angesehen: Pharma-kologisch-neurobiochemisch bewirken sie eine se...
