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  1. No Access

    Chapter and Conference Paper

    5-HIAA and HVA in the Coma Cerebri, Hydrocephalus and Tumor Cerebri

    The concentration of metabolites of neurohormones in cerebrospinal fluid (CSF) is an index of turnover of substances in brain. 5-Hydroxyindoleacetic acid (5-HIAA) – serotonine metabolite and homovanillic acid ...

    M. Salihović, E. Sofić in CMBEBIH 2017 (2017)

  2. No Access

    Article

    Brain catalase in the streptozotocin-rat model of sporadic Alzheimer’s disease treated with the iron chelator–monoamine oxidase inhibitor, M30

    Low intracerebroventricular (icv) doses of streptozotocin (STZ) produce regionally specific brain neurochemical changes in rats that are similar to those found in the brain of patients with sporadic Alzheimer’...

    E. Sofic, M. Salkovic-Petrisic, I. Tahirovic, A. Sapcanin… in Journal of Neural Transmission (2015)

  3. No Access

    Article

    Antioxidant capacity in rat brain after ICV treatment with streptozotocin and alloxan — a preliminary study

    Intracerebroventricular (icv) administration of betacytotoxic drug streptozotocin (STZ) produces long-term and progressive cognitive deficits in rats, as well as deficits in cerebral glucose and energy metabol...

    A. Sapcanin, E. Sofic, I. Tahirovic, M. Salkovic-Petrisic… in Neurotoxicity Research (2008)

  4. No Access

    Article

    The effects of exogenous melatonin on the morphology of thyrocytes in pinealectomized and irradiated rats

    We investigated the effects of exogenous melatonin on the thyrocytes morphology in gamma-irradiated rats under condition where the pineal gland, as a main physiological source of endogenous melatonin, was remo...

    Z. Kundurovic, E. Sofic in Journal of Neural Transmission (2006)

  5. No Access

    Article

    Antioxidant capacity of the neurohormone melatonin

    The aim of this study was to elucidate the antioxidant behaviour of melatonin (M) and determine its activity–structure relationship. M or 5-metoxy-N acetyltriptamine is a neurohormone secreted by the pineal gl...

    E. Sofic, Z. Rimpapa, Z. Kundurovic, A. Sapcanin… in Journal of Neural Transmission (2005)

  6. No Access

    Article

    Serum antioxidant capacity in neurological, psychiatric, renal diseases and cardiomyopathy

    The role of free radicals (FR) in the pathogenesis and in the progression of many diseases has been often discussed, but not widely investigated. However, the total antioxidant capacity in the serum seems to ...

    E. Sofic, A. Rustembegovic, G. Kroyer, G. Cao in Journal of Neural Transmission (2002)

  7. No Access

    Article

    Antioxidant and pro-oxidant capacity of catecholamines and related compounds. Effects of hydrogen peroxide on glutathione and sphingomyelinase activity in pheochromocytoma PC12 cells: potential relevance to age-related diseases

    The antioxidant and pro-oxidant capacity of catecholamines (CA) and related compounds were analyzed using the oxygen radical absorbance capacity (ORAC) assay. In the assay 2,2′-azobis (2-amidino-propane) dihy...

    E. Sofic, N. Denisova, K. Youdim, V. Vatrenjak-Velagic… in Journal of Neural Transmission (2001)

  8. No Access

    Article

    Depression in Parkinson's disease: biogenic amines in CSF of “de novo” patients

    Introduction. Etiology of depression in Parkinsons disease (PD) is associated with serotonergic dysfunction. Previous studies, supporting this hypothesis, were performed on patients treated with antiparkinsonian...

    W. Kuhn, Th. Müller, M. Gerlach, E. Sofic, G. Fuchs… in Journal of Neural Transmission (1996)

  9. No Access

    Chapter and Conference Paper

    Adrenerg-cholinerge Gleichgewichtshypothese der Depression: der α2-adrenerge Agonist Clonidine antagonisiert nicht das Physostigmin-Syndrom

    In Ubereinstimmung mit der adrenerg-cholinergen Gleichgewichtshypothese affektiver Psychosen [13] reagierten affektiv Kranke überempfindlich gegen hirngängige Cholinomimetika wie Physostigmin (PHY) auf Ebene v...

    Dr. J. Fritze, M. Lanczik, K. Maurer, E. Sofic… in Biologische Psychiatrie der Gegenwart (1993)

  10. No Access

    Chapter and Conference Paper

    Verteilung von Kainatrezeptoren im menschlichen Gehirn

    Glutamat ist eine Aminosäure, die im Gehirn von Säugern weitverbreitet ist und den wichtigsten exzitatorischen Neurotransmitter darstellt [3, 4, 5]. Diese exzitatorische Aminosäure wird vor allem von kortikale...

    Dr. K. W. Lange, E. Oestreicher, U. Fischer… in Biologische Psychiatrie der Gegenwart (1993)

  11. No Access

    Chapter and Conference Paper

    Biochemische Hypothesen psychogeriatrischer Erkrankungen

    Die Anzahl alter Menschen an der Gesamtbevölkerung hat in den entwickelten Industrienationen in diesem Jahrhundert stark zugenommen und wird noch weiter steigen. Daher besteht ein großes Forschungsinteresse an...

    P. Riederer, L. Frölich, M. Götz, G. Moll, W. Gsell… in Psychische Krankheit im Alter (1993)

  12. No Access

    Chapter and Conference Paper

    Butyryl-Cholinesterase, biogene Amine und akustisch evozierte P300 nach cholinerger Modulation bei Probanden

    Die Abhängigkeit kognitiver Funktionen von der Aktivität des zentralen cholinergen Neurotransmittersystems ist seit langem bekannt (Drachman 1977). Bei gesunden Probanden führt die Hemmung der cholinergen Neur...

    L. Frölich, R. Ihl, E. Sofic, T. Müller, T. Dierks, K. Maurer in Biologische Psychiatrie (1992)

  13. No Access

    Chapter and Conference Paper

    Das psychotrope Wirkprofil neuentwickelter substituierter Benzamide

    Substituierte Benzamide werden bislang aufgrund ihres speziellen pharmakologischen Wirkprofils als eigenständige Gruppe psychotroper Substanzen angesehen: Pharma-kologisch-neurobiochemisch bewirken sie eine se...

    G. Laux, W. Classen, T. Becker, M. Struck, E. Sofic, P. Riederer… in Biologische Psychiatrie (1992)

  14. No Access

    Article

    Biogenic amines and metabolites in spinal cord of patients with Parkinson's disease and amyotrophic lateral sclerosis

    In four human controls, four cases of Parkinson's disease and three cases of amyotrophic lateral sclerosis analysis of dopamine, noradrenaline, serotonin and the metabolites 3,4-dihydroxyphenylacetic acid, hom...

    E. Sofic, Univ.-Prof. Dr. P. Riederer… in Journal of Neural Transmission - Parkinson… (1991)

  15. No Access

    Chapter and Conference Paper

    Brofaromine (CGP 11 305 A): estimation of plasma concentrations by a biologic technique as compared to liquid chromatography

    In an open clinical trial 13 depressives significantly improved under the reversible and selective type-A monoamine oxidase (MAO) inhibitor brofaromine. The inhibitory potency of deproteinated plasma on a crud...

    Dr. J. Fritze, Th. Becker, V. Ziegler… in Amine Oxidases and Their Impact on Neurobi… (1990)

  16. No Access

    Chapter and Conference Paper

    Clinical, biochemical and psychometric findings with the new MAO-A-inhibitors moclobemide and brofaromine in patients with major depressive disorder

    N = 53 inpatients with major depressive disorder have been treated with the reversible, selective MAO-A-inhibitors moclobemide (double-blind versus maprotiline) and brofaromine (open study), respectively. Clin...

    Dr. G. Laux, W. Classen, E. Sofic, T. Becker… in Amine Oxidases and Their Impact on Neurobi… (1990)

  17. No Access

    Chapter and Conference Paper

    Reflection of changes in membrane constituents in various regions of Alzheimer brains to differential scanning thermograms

    To test whether changes in basic biochemical membrane constituents were reflected in membrane fluidity measurements, protein, total lipids, triglycerides, lecithine, cholesterol and alkaline phosphatase were d...

    E. Sofic, M. Götz, Dr. L. Frölich, R. Burger… in Amine Oxidases and Their Impact on Neurobi… (1990)

  18. No Access

    Chapter

    Senile dementia of Alzheimer’s type and Parkinson’s disease: neurochemical overlaps and specific differences

    Parkinson’s disease (PD) is characterized by a clear rank order with respect to neuropathological findings. Both substantia nigra (SN) and locus coeruleus (LC) are severely damaged, whilst nucleus raphe dorsal...

    P. Riederer, E. Sofic, G. Moll… in Early Markers in Parkinson’s and Alzheimer… (1990)

  19. No Access

    Chapter and Conference Paper

    Urinary dopamine sulfate: regulations and significance in neurological disorders

    Dopamine-3-O-sulfate (DA-3-O-S) and dopamine-4-O-sulfate (DA-4-O-S) are important end products of L-dopa metabolism. Therefore they may give indications of disturbances in the peripheral metabolism of catechol...

    E. Kienzl, K. Eichinger, E. Sofic… in Amine Oxidases and Their Impact on Neurobi… (1990)

  20. No Access

    Article

    Plasma moclobemide and metabolites: lack of correlation with clinical response and biogenic amines

    The concentration of the reversible monoamine oxidase type-A (MAO-A) inhibitor moclobemide (Ro 11-1163) was determined by high pressure liquid chromatography (HPLC) in the plasma of 16 depressives treated with...

    J. Fritze, G. Laux, E. Sofic, P. Koronakis, M. P. Schoerlin… in Psychopharmacology (1989)

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